3.5 Kemoterapija Virusnih Okužb Flashcards

1
Q

Zaviralci virusne DNA polimeraze

A
  1. Idoksuridin
  2. Trifluridin
  3. Vidarabin
  4. Citarabin
  5. Aciklovir
  6. Ganciklovir
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2
Q

Spekter delovanja zaviralcev virusne DNA polimeraze

A
  • herpes simplex (vsi razen ganciklovir)
  • varičela zoster (vidarabin in citarabin
  • citomegalovirusi (ganciklovir)
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3
Q

Kaj uporabljamo za hudo okužbo z virus herpes simplex?

A
  • vidarabin - npr. Encefalitis, herpes pri novorojenčkih
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4
Q

Ribavarin delovanje

A
  • zavira replikacijo in transkripcijo virusne DNA
  • inhibira virusne polimeraze in prepreči izdelovanje virusnih mRNA
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5
Q

Ribavirin - za katere viruse?

A
  • virusi influenze
  • respiratorni sincicjski virus
  • nekateri bunjavirusi
  • arenavirusi
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6
Q

Česa ne moremo zdravit z aciklovirjem in zakaj

A
  • okužb z EBV in citomegalovirusi
  • ker nimata lastne timidin kinaze
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7
Q

Zaviralci reverzne transkriptaze

A
  • zidovudin
  • zalcitabin
  • lamivudin
  • didanozin
  • nevirapin
  • delaviridin
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8
Q

Spekter delovanja zaviralcev RT?

A
  • hiv
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9
Q

Zaviralci virusne proteaze

A
  • sakvinavir
  • indinavir
  • ritonavir
  • nelfinavir
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10
Q

Spekter delovanja zaviralcev proteaz

A
  • hiv
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11
Q

kateri preprečijo slačenje virusa + spekter delovanja

A
  • amantadin in rimantadin (virus influenze A)
  • arilodon (virus herpes simplex)
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12
Q

Katera zdravila uporabljamo v kombinaciji? Zakaj je to dobro?

A

Zidovudin + zalcitabin/lamivudin/didanozin
- manjše doze + manjše tveganje za razvoj odpornosti

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13
Q

Kako deluje metisazon?

A
  • prepreči translacijo virusne mRNA
  • poksvirusi
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14
Q

Kako deluje fosfomravljična kislina?
+ za katere viruse se uporablja lahko

A
  • zavira virusno DNA polimerazo
  • virus herpes simplex
  • citomegalovirus
  • virus hepB
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