34b - Polyoma Viruses

Question 1

Characteristics of polyoma virus?

Answer 1

subfamily papilloma
circular dsDNA genome
nonenveloped, icosahedral capsid

Question 2

What are the two known polyoma viruses?

Answer 2

BK and JC

Question 3

Where are BK and JC found?

Answer 3

BK - 50% of 3 to 4 year olds

JC - 50% of 10-14 year olds

Question 4

What is the problem with BK and JC?

Answer 4

they can transform cell lines and cause tumors.

Really tends to only be a problem in immunocompromised.

Question 5

What does JC cause?

Answer 5

progressive multifocal leukoencephalopathy

-a demyelinating disease that kills within 3-6 months. infects and nlyses oligodnedrocytes

Question 6

How is JC diagnosed?

Answer 6

MRI to detectl esions

PCR amplif from infected brain or CSF

Question 7

What is treatment for PML (progressive multifocal leukoencephalopathy)?

Answer 7

none they are fucked. Cut back on immunosuppression if transplant. Adjust HAART in AIDS.