Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuro weeks4-6 - Keith > 31c - Brain Tumor ChemRx > Flashcards

31c - Brain Tumor ChemRx Flashcards

1
Q

MOA of carmustine

A

Nitrosourea. alkylator AND its decomposition products carbamoylate proteins to inhibit DNA repair

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ADE of carmustine?

A

thrombocytopenia, leucopenia, pulmonary fibrosis, endocrine dysfunction
encephalopathy and seizures
elevated LFT and hyperbilirubinemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MOA of temozolomide

A

DNA methylator. non-enzymatically activated pro-drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ADE of temozolomide

A

N/v chills, fever, malaise, myalgia,

DOSE DEPENDENT myelosuppessive effects due to low MGMT production by hamtopoietic stem cells (they get killed)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Should chemo be used to treat brain mets?

A

lack of evidence to support treatment of patients with brain mets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are mechanisms of brain tumor drug resistance?

A

BBB, epxression of PgP by metastatic cells, and astrocyte mediated resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Neuro weeks4-6 - Keith (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions