28b - Drugs for Insomnia Flashcards
1
Q
MOA of estazolam
A
benzodiazepine
2
Q
MOA of flurazepam
A
benzodiazepine
3
Q
MOA of quazepam
A
benzodiazepine
4
Q
MOA of temazepam
A
benzodiazepine
5
Q
MOA of triazolam
A
benzodiazepine
6
Q
MOA of doxepin
A
antidepressant
7
Q
MOA of mirtazapine
A
antidepressant
8
Q
MOA of trazodone
A
antidepressant
9
Q
MOA of zolpidem
A
benzodizepine receptor agonist
10
Q
MOA of zaleplon
A
benzodizepine receptor agonist
11
Q
MOA of eszopiclone
A
benzodizepine receptor agonist
12
Q
MOA of ramelteon
A
melatonin receptor agonist
13
Q
MOA of diphenhydramine
A
1st gen antihistamine
14
Q
MOA of doxylamine
A
1st gen antihistamine
15
Q
What are the 2 arousal pathways?
A
- Ach cells from upper pons, PPT and LDT activate thalamus
- activation of cerebral cortex so it can receive thalamic inputs.
- histamine from TMN
- dopamine from A10 cell group
- serotonin from dorsal and median raphe
- noradrenaline from locus coeruleus
- orexin and melanin-concentrating hormone from lateral hypothalamus (LHA)
- GABA or Ach from Basal forebrain