3.4 Mass transport Flashcards
What is the structure of haemoglobin?
- Haemoglobin is a protein making up 95% of the dry mass of a red blood cell. It is the means of transport of oxygen around the body
- Haemoglobin is made up of four polypeptide chains, each bound to one haem group
- Each haem group can combine with one oxygen molecule, so that one molecule of haemoglobin can combine with a maximum of four oxygen molecules. This forms oxyhaemoglobin
What is the shape of the curve in the oxygen dissociation graph?
- An oxygen dissociation curve is an S shape curve.
- The curve is this shape because the first oxygen finds it difficult to bind to one of the sites on its 4 polypeptide subunits because they are closely united.
- Therefore at low oxygen concentrations, little oxygen binds to haemoglobin - the gradient of the curve is shallow initially
- Once the first one has bound it changes the shape of the haemoglobin so the next 3 oxygens find it easier to bind.
- This is sometimes called a conformational change
What does the curve shifted to the right mean in an oxygen dissociation graph?
- Any curve that is shifted to the right is an animal with haemoglobin with a low affinity for oxygen
- Animals with a large surface area:volume ratio are in danger of losing body heat
- They need to maintain body temperature by having a high respiratory rate to generate heat respiration requires oxygen
- Active animals have a high respiratial rate to release energy for muscle contraction
- The further to the right the curve, the lower is the affinity of haemoglobin for oxygen
What is the BOHR shift?
- High concentrations of CO2 causes a shift to the right. This is knows as the Bohr shift. It means oxygen is more readily released to tissues
What does the curves shifted to the left mean on an oxygen dissociation graph?
- The llama and foetal haemoglobin have a curve that has been shifted to the left of the human haemoglobin
- Organisms on the left of the curve for humans can pick up oxygen easily if there is not much available
- The further to the left the curve, the greater is the affinity of haemoglobin for oxygen
What is the structure and function of veins?
- Walls are thin and contain 4 layers of tissue: epithelium, muscle layer, elastic tissue and collagen
- Carries blood at low pressure (10 to 20mmHg)
- Leads towards the heart
- Contains valves to stop backflow
- Mostly under the surface of the skin
- Lumen diameter very large - many RBCs flow at once
- Wall thin because pressure is low
What is the structure and function of arteries?
- Walls are very thick and contain 4 layers: epithelium, muscle layer, elastic tissue and collagen
- Carries blood at systolic pressure (120mmHg)
- Leads away from the heart
- Contains no valves
- Mostly deep beneath the skin
- Lumen diameter fairly large - many RBCs flow, but closely packed together
- Wall contains thick muscle layer to cope with very high internal pressure
What is the structure and function of the capillaries?
- Walls are made from one layer of epithelium cells
- Carries blood at very low pressure (1 to 2mmHg)
- Not connected to the heart
- Contains no valves
- Found throughout all tissue
- Lumen diameter small - one RBC passes through at a time
- Wall bursts under pressure changes
What does oxygenated mean?
Blood with oxygen (usually coloured red on a diagram)
What does deoxygenated mean?
Blood with low oxygen (usually coloured blue on a diagram)
What is a pulmonary vein?
Blood vessel which returns with oxygenated blood from the lungs to the left atrium
What is a pulmonary artery?
Blood vessel which leaves the right ventricle transporting deoxygenated blood to the lungs
What is the aorta?
The major blood vessel, which carries, oxygenated blood from the heart to the body
What is the ventricle?
One of the bottom two chambers of the heart
What is the atrium?
One of the top two chambers of the heart
What is the atrioventricular valve?
The valve which prevent backflow from the ventricles to the atria
What is the vena cava?
The major blood vessel which returns deoxygenated blood to the heart from the body
What are the semi lunar valves?
The valves which prevent backflow from the arteries to the ventricles
What is the septum?
Separates the two sides of the heart, keeping oxygenated and deoxygenated blood apart
What are the coronary arteries?
Blood vessels on the surface of the heart, which supply the heart itself with blood
What is mass flow?
Mass flow essentially means the transport of lots and lots of substances through the circulatory system. The continual movement is caused by the heart pumping
What is the first stage of the cardiac cycle?
- Blood enters atria and ventricles from pulmonary veins and vena cava
- Semi-lunar valves closed
- Left and right atrioventricular valves open
- Relaxation of ventricles allows blood to enter from atria
- Relaxation of heart (diastole)
- Atria are relaxed and fill with blood. Ventricles are also relaxed
What is the second stage of the cardiac cycle?
- Atria contract to push remaining blood into ventricles
- Semi-lunar valves closed
- Left and right atrioventricular valves open
- Blood pumped from atria to ventricles
- Contraction of atria (atria systole)
- Atria contract, pushing blood into the ventricles. Ventricles remain relaxed
What is the third stage of the cardiac cycle?
- Blood pumped into pulmonary arteries and the aorta
- Semi-lunar valves open
- Left and right atrioventricular valves closed
- Ventricles contract and walls thicken
- Contraction of ventricles (ventricular systole)
- Atria relax. Ventricles contract, pushing blood away from heart through pulmonary arteries and the aorta
What is relaxation of the heart?
- Blood returns to the atria of the heart through the pulmonary vein and the vena cava.
- As the atria fill, the pressure in them rises.
- When this pressure exceeds that in the ventricles, the atrioventricular valves open, allowing the blood to pass into the ventricles.
- The passage of blood is aided by gravity.
- The muscular walls of the atria and ventricles are relaxed, which causes them to recoil and reduces the pressure within the ventricles.
- This causes the pressure to be lower than that in the aorta and the pulmonary artery, and so the semi-lunar vales in the aorta and pulmonary artery close.
What is the contraction of the atria (atrial systole)?
The contraction of the atrial walls, along with the recoil of the relaxed ventricle walls, forces the remaining blood into the ventricles from the atria.
Throughout this stage the muscle of the ventricle walls remains relaxed.
The semi lunar valves stay closed and the atrioventricular valves open.
What is the contraction of the ventricles (ventricular systole)?
After a short delay to allow the ventricles to fill with blood, their walls contract simultaneously.
This increases the blood pressure within them, forcing shut the atrioventricular valves and preventing backflow of blood into the atria.
The pressure in the ventricles rises further, once it exceeds that in the aorta and pulmonary artery, blood is forced from the ventricles into these vessels.
What are pocket valves?
In veins that occur throughout the venous system.
These ensure that when the veins are squeezed, e.g. when skeletal muscles contract, blood flows back towards the heart rather than away from it.
What is the structure of a haemoglobin molecule?
- Primary structure - Sequence of amino acids in the four polypeptide chains
- Secondary structure - in which each of these polypeptide chains is coiled into a helix
- Tertiary structure - in which each polypeptide chain is folded into a precise shape - an important factor in its ability to carry oxygen
- Quaternary structure - in which all four polypeptide are linked together to form an almost spherical molecule. Each polypeptide is associated with a haem group - which contains a ferrous ion. Each ion can combine with a single oxygen molecule, making a total of four oxygen molecules that can be carried by a single haemoglobin molecule in humans
What are haemoglobins?
Protein molecules with a quaternary structure that has evolved to make it efficient at loading oxygen under one set of conditions but unloading it under a different set of conditions
Explain loading and unloading oxygen.
- The process by which haemoglobin binds with oxygen is called loading, or associating. In humans this takes place in the lungs
- The process by which haemoglobin releases its oxygen is called unloading, or dissociating. In humans this takes place in the tissues
What does having a high affinity mean for haemoglobin?
Haemoglobins with a high affinity for oxygen take up oxygen more easily, but release it less easily
What does having a low affinity mean for haemoglobin?
Haemoglobins with a low affinity for oxygen take up oxygen less easily , but release it more easily
What is the role of haemoglobin?
- The role of haemoglobin is to transport oxygen
What does haemoglobin need to do to be efficient at transporting oxygen?
- Readily associate with oxygen at the surface where gas exchange takes place
- Readily dissociate from oxygen at those tissues requiring it
Why are there different haemoglobins?
- Scientists observed that many organisms possessed haemoglobin
- They proposed that it carried oxygen from the gas-exchange surface to the tissues that required it for respiration - this meant that it must readily combine with oxygen
- Consequently they investigated the ability of haemoglobin from different organisms to combine with oxygen
- Results showed that there were different types of haemoglobins
- These exhibited different properties relating to the way they took up and released oxygen