3.4 - CAPILLARIA PHILIPPINENSIS Flashcards
natural host
migratory fish-eating birds
intermediate host
brackish/fresh water fish
final/accidental host
man
habitat
small intestine
MOT
ingestion of larva (from raw fish)
infective stage
larval stage (in fish)
diagnostic stage
egg
The first case of Capillaria philippinensis was discovered in ?, hence the name of the species.
Ilocos Norte in 1963
produce eggs that hatch outside the body of the mother; lay undeveloped eggs
Oviparous
produce eggs that hatch within the mother; produce embryonated eggs
Ovoviviparous
immediately bears larvae
Larviparous
- Secretory cells
- Found along the esophagus of the parasite
Stichocytes
- Entire esophageal structure with stichocytes
- A collection of stichocytes
Stichosome
2 modes of reproduction
- typical
- atypical
mode of reproduction: oviparous
Typical
mode of reproduction: ovoviviparous, larviparous
Atypical
- 1.5-3.9 mm
- spicule: 230-300 um
- unspined sheath
male adult
- 2.3-5.3 mm
- can be either oviparous, ovoviviparous, larviparous
female
egg shape
peanut or guitar shaped
unique diagnostic characteristic of eggs
- thick radially striated cells
- flattened bipolar mucus plugs
- 36 to 45um by 20 um
stage of the parasite in the infected fish; infective stage of Capillaria philippinensis in man
L3 Filariform larva
life cycle
- ingestion of raw infected fish
- small intestine
- larva to adult
- copulation
- lay eggs
- if unembryonated - passed to stool; new cycle of infection
- if embryonated - autoinfection -> hyperinfection
Infective stage in intermediate host:
embryonated egg
Infective stage in final host:
larva lodged into the intestine
or the mean of undercooked or raw fish
fish that has higher parasitic yield
Bagsit (Hypseleotris bipartita)
intestinal capillariasis
mystery disease or Pudoc disease
chronic diarrhea
8-10 voluminous stool per day
gurgling stomach
Borborygmus
- severe diarrhea
- electrolyte imbalance
chronic diarrhea
other clinical manifestations
- abdominal pain
- protein-losing enteropathy
- hypoalbuminemia
- intestianal malabsorption
- hypoproteinemia
diagnostic tests
- DFS
- kato thick
- concentration test
- ELISA
- detects coproantigen
- disadvantage: cross reaction with Trichinella spiralis antigen
ELISA (enzyme-linked immunosorbent assay)
- First recorded in the Philippines
- Endemic in the Philippines and Thailand
- Mystery disease - Compostela Valley
epidemiology
treatment
mebendazole
other Capillaria spp
- Capillaria hepatica
- Capillaria aerophilia
causes the human hepatic Capillariasis
Capillaria hepatica
causes the human pulmonary Capillariasis
Capillaria aerophilia
pathogenesis and clinical manifestations of other Capillaria spp
- Asymptomatic
- Heavy infections can cause gastrointestinal problems
- Abdominal pain
- Diarrhea
- Anorexia
- Headache
- Fatigue
- Anemia
- Eosinophilia
diagnosis for other Capillaria spp
- DFS
- concentration test