3.1 - ASCARIS LUMBRICOIDES Flashcards

1
Q

Phylum

A

Nemathelminthes

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2
Q

Class

A

Nematoda

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3
Q

3 types of musculature of nematodes

A
  • polymyarian
  • meromyarian
  • holomyarian
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4
Q

more than five rows of cells

A

polymyarian

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5
Q

between two to five rows of cells

A

meromyarian

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6
Q

less than two rows of cells

A

holomyarian

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7
Q

Intestinal Species (7)

A
  • Ascaris lumbricoides
  • Trichuris trichiura
  • Enterobius vermicularis
  • Capillaria philippinensis
  • Ancylostoma duodenale
  • Necator americanus
  • Strongyloides stercoralis
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8
Q

Tissue Species (2)
Blood Species (4)

A
  • Trichinella spiralis
  • Dracunculus medinensis

Blood Species:
- Wuchereria bancrofti
- Brugia malayi
- Onchocerca volvulus
- Loa loa

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9
Q

Animal Species

A
  • Ancylostoma caninum
  • Ancylostoma braziliense
  • Toxocara cati
  • Toxocara canis
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10
Q
  • nonsegmented, cylindrical, symmetrical
  • cuticle - protective covering
  • complete digestive tract
  • dioecious - separate sexes
  • chemoreceptors
A

General Morphology of Nematodes

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11
Q

chemoreceptors

A
  • amphid
  • aphasmid
  • phasmid
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12
Q

amphid

A

with head/cephalic

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13
Q

aphasmid

A

absence of phasmid (tail)

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14
Q

phasmid

A

with tail/caudal

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15
Q

all nematodes have ?

A

amphids

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16
Q

all nematodes have phasmids except: (they have ?)

A
  • Trichuris trichiura
  • Capillaria philippinensis
  • Trichinella spiralis

stichocytes (secretory cells)

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17
Q

all nematodes inhabit the small intestine except: (what do they inhabit?)

A
  • Enterobius vermicularis
  • Trichuris trichiura

large intestine

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18
Q

life cycle of nematodes

A

eggs
- unfertilized
- fertilized
- embryonated –> infective stage

larva
- rhabditiform
- filariform (3rd larval stage, infective stage, L3)

adult –> most mature stage

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19
Q

MOT: ingestion

through eggs

A

Ascaris, Trichuris, Enterobius

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20
Q

MOT: ingestion

through larva

A

Capillaria, Angiostrongylus, Trichinella

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21
Q

MOT: skin penetration

A

Hookworms, Strongyloides

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22
Q

MOT: inhalation

A

Enterobius vermicularis

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23
Q

MOT: transmammary

A

S. stercoralis, A. duodenale

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24
Q

MOT: vectors

A

filarial worms

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25
Q

common names

Ascaris lumbricoides

A

giant intestinal round worm

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26
Q

common names

Enterobius vermicularis

A

pin worm, seat worm, society worm

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27
Q

common names

Trichuris trichiura

A

human whip worm

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28
Q

common names

Capillaria philippinensis

A

pudoc worm

29
Q

common names

Ancylostoma duodenale

A

old world hookworm

30
Q

common names

Necator americanus

A

new world hookworm/American murderer

31
Q

common names

Strongyloides stercoralis

A

Threadworm

32
Q

common names

Ancylostoma caninum

A

dog hookworm

33
Q

common names

Ancylostoma braziliense

A

cat hookworm

34
Q

common names

Ancylostoma ceylanicum

A

civet cat found in Ceylon Sri Lanka

35
Q
  • largest intestinal roundworm
  • soil transmitted helminth
A

Ascaris lumbricoides

36
Q

definitive host of A. lumbricoides

A

man

37
Q

habitat of A. lumbricoides

A

small intestine

38
Q

MOT of A. lumbricoides

A

ingestion of eggs

39
Q

infective stage of A. lumbricoides

A

embryonated egg

40
Q

diagnostic stage of A. lumbricoides

A

egg and adult worm

41
Q
  • creamy-white to pink in color
  • oviparous (unembryonated eggs)
  • spicules (copulatory organs)
A

general morphology of A. lumbricoides

42
Q

unique diagnostic feature of A. lumbricoides

A

trilobate lips

43
Q
  • 20-35 cm in length
  • pointed or straight tail
  • oviparous (200,000 eggs per day)
A

female adult A. lumbricoides

44
Q
  • <30cm length
  • curved tail, bent or coiled
  • spicules
A

male adult A. lumbricoides

45
Q
  • 88um to 94um by 39 to 44um
  • Longer, Narrower
  • More oval or oblong in shape
  • Thin Egg Shell
  • Irregular mammilated coating with refractile granules
  • Outer layer of the unfertilized egg
  • will never mature
  • sign that female adults are inside
A

unfertilized eggs

46
Q
  • 45 to 70um by 35 to 50um
  • Coarsely mammillated albuminous covering
  • Thick outer layer as supporting structure
  • Delicate vitelline, lipoidal inner membrane
  • Underneath the thick mammilated albuminous covering
  • more defined
  • capable of embryonation
A

fertilized eggs

47
Q

outer layer of fertilized egg

A

coarsely mammillated albuminous covering

48
Q

middle layer of fertilized egg

A

glycogen layer

49
Q

inner layer of fertilized egg

A

lipoidal inner membrane

50
Q
  • infective mature stage
  • needs soil to be ?
  • contains the larvae
  • can be corticated or decorticated
A

embryonated eggs

51
Q

thick outer shell

A

corticated

52
Q

lost the mammillated covering

A

decorticated

53
Q

it takes ? for fertilized eggs to become embryonated and to be infective

A

2-3 weeks

54
Q

life cycle of ascaris

A
  1. mouth
  2. small intestine
  3. lymphatic vessel
  4. lungs
  5. throat
  6. cough
  7. swallow
  8. small intestine
  9. adult
  10. mate
  11. feces
  12. soil
  13. embryonate
55
Q

the female ascaris lays ? eggs per day

A

200,000

56
Q
  • ascariasis
  • Loffler syndrome
  • bowel obstruction with fever and malaise
  • intestinal perforation and migration
  • occlusion of appendix
  • lactose maldigestion
A

pathogenesis and clinical manifestations

57
Q

Ascaris infection

A

Ascariasis

58
Q
  • pneumonitis
  • Disease manifested during lung migration
  • Bilateral diffuse, mottled pulmonary infiltrates and mild bronchitis associated with peripheral eosinophilia
A

Loffler Syndrome

59
Q

Virulence Factors

A
  • Pepsin inhibitor 3 (PI-3)
  • Phosphorylcholine
60
Q
  • Pepsin: enzyme produced by the parietal cells of the stomach that aids in protein or food digestion
  • Protects worm from digestion
  • Safely pass through the stomach and lodge into the small intestine
  • Evade the juices of digestive tract
A

Pepsin Inhibitor 3 (PI-3)

61
Q

Suppresses lymphocyte proliferation

A

Phosphorylcholine

62
Q

diagnosis

A
  • DFS
  • kato thick smear
  • concentration test
63
Q

extraintestinal organs affected by ascaris

A

liver, gallbladder, pancreas, bile ducts,

64
Q
  • An estimated 807 million-1.3 billion people in the world
  • Poor personal hygiene, poor sanitation, and in places where human feces are used as fertilizer
A

epidemiology

65
Q

treatment

A

drug of choice: albendazole

66
Q

related to Ascaris lumbricoides

A

Ascaris suum

67
Q

common name of Ascaris suum

A

pig roundworm

68
Q

Ascaris suum is high risk for people who?

A

raise pigs or use raw pig manure as fertilizer