3.3.1 Bio exp.1: Dopamine Hypothesis Flashcards
What did the initial hypothesis propose about SCZ?
That schizophrenia was caused by an excess of the neurotransmitter dopamine
What were symptoms of SCZ related to?
Symptoms of SCZ were related to high levels of dopamine
What did the supporting research in 1968 by J.J. Griffith involve?
He induced psychosis by giving
Non-schizophrenic volunteers dextro-amphetamine (a drug that increases dopamine)
What were the findings of the supporting research in 1968 by J.J. Griffith?
Volunteers developed paranoid delusions and showed cold, detached emotional responses
What is the negative about the initial dopamine hypothesis?
- It was considered too simplistic
- Evidence showed that drugs reducing dopamine levels had little or no effect on individuals primarily suffering from the negative symptoms of schizophrenia
Where are the D1-D5 receptors found?
In the sub-cortical regions and the cerebral cortex
e.g limbic system
What did Seeman and Lee (1975) highlight?
They highlighted the impact of anti-psychotic drugs on D2 receptors
What is the Limbic System
Subcortical structures that are involved in emotions, memory formation and arousal
