3.1.2- Transport in Animals Flashcards

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1
Q

what are the four types of circulatory systems?+

A
  • open
  • closed
  • single
  • double
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2
Q

what type of circulatory system do insects, fish and mammals have?

A
  • insects= open circuit
  • fish= closed, single circuit
  • mammals= closed, double circuit
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3
Q

what do all mass transport/circulatory systems have?

A
  • fluid/medium to carry nutrients and oxygen
  • tubes/vessels to carry transport medium
  • pumping mechanism to create pressure to move/push fluid around the body.
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4
Q

what is the function of ARTERIES?

A

= to send blood from the heart

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5
Q

what is the function of VEINS

A

=to send blood to the heart

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6
Q

what is the function of CAPILLARIES?

A

= to exchange material with tissue.

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7
Q

what do arteries branch off into?

A

arterioles

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8
Q

what do veins branch off into?

A

venules

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9
Q

what are the four layers that arteries and veins contain?

A
  • collagen fibres
  • smooth muscle
  • elastic fibres
  • lumen endothelium
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10
Q

which vessel has the thickest wall?

A

= arteries

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11
Q

what does the structure of the artery include

A
  • narrow lumen
  • thick wall
  • large amounts of smooth muscle and elastic fibres
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12
Q

what are the elastic fibres in artery walls do?

A
  • enable the artery to withstand the force of the blood pumped out of the heart
  • stretch to take larger volumes of blood
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13
Q

why do arteries have smooth muscle

A

it is smooth so that blood can easily flow over it

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14
Q

why do arterioles have more smooth muscle and less elastic fibres compared to arteries?

A
  • little pulse surge

- muscles can constrict/dilateto control blood flow into organs.

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15
Q

what is VASCOCONSTRICTION

A

when the smooth muscle in the arteriole contracts, it constricts the vessel, which then prevents blood flow into the capillary bed.

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16
Q

what is VASODILATION?

A

when the smooth muscle relaxes, blood flows through the capillary bed

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17
Q

what are the components of veins?

A
  • wide lumen
  • thin wall
  • small amount of muscle + elastic fibres
  • valves
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18
Q

which vessel has high pressure?

A

artery

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19
Q

which vessels have low pressure?

A

veins + capillary.

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20
Q

how are capillaries structured for their role?

A
  • large surface area for diffusion in/out of blood.
  • total cross sectional area is greater than the arteriole supplying them, rate of blood flow falls
  • walls are one endothelial cell thick, thin layer for diffusion.
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21
Q

why do veins contain valves?

A

to prevent the backflow of blood.

valves close when blood tries to flow backwards.

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22
Q

how much of a human’s blood volume is in the veins at one time?

A

up to 60%

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23
Q

when does blood move along veins?

A

when skeletal muscles contract.

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24
Q

what is the order of flow of blood?

A

artery–> arterioles–> capillaries–> venules–> veins

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25
Q

what are the four components of the blood?

A
  • erythrocytes (red blood cells)
  • platelets
  • leucocytes (white blood cells)
  • plasma
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26
Q

what does the blood plasma contain?

A
  • glucose
  • amino acids
  • mineral ions
  • hormones
  • carbon dioxide
  • oxygen
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27
Q

what is tissue fluid?

A

a liquid that contains oxygen and nutrients, supplying tissues with essential solutes in exchange for waste products.

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28
Q

the amount of liquid that leaks from the capillary to form tissue fluid depends on what?

A
  • relative hydrostatic pressure

- oncotic pressure

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29
Q

what is hydrostatic pressure ?

A

the surge of blood that occurs every time the heart contracts

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30
Q

what is oncotic pressure?

A

the tendency of water to move into the blood by osmosis

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31
Q

how is tissue fluid formed?

A

when the hydrostatic pressure is higher than oncotic pressure, water is attracted in to the capillary, so fluid is squeezed out
this fluid fills the spaces between cells.

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32
Q

how do you work out filtration pressure?

A

hydrostatic pressure - oncotic pressure

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33
Q

how does tissue fluid become lymph?

A

tissue fluid drains into lymphatic vessel through the one way valves, becoming lymph.

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34
Q

what is lymph?

A

the large molecules that cannot pass through the capillary wall (and can’t become tissue fluid or drain into the blood)

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35
Q

what are lymph capillaries like?

A
  • closed ends
  • large pores, allowing large molecules to pass through
  • separate from the circulatory system
  • liquid moves along them by compression caused by body movement
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36
Q

where does lymph reenter the blood stream?

A

through veins near the heart.

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37
Q

what is the composition of blood?

A

red blood cells, white blood cells, platelets and plasma

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38
Q

what is the composition of tissue fluid?

A

O2 , CO2 , sugars, salts, amino acids, hormones, coezymes & white blood cells.

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39
Q

what is the composition of lymph?

A

carbon dioxide, proteins, glucose and white blood cells

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40
Q

how many chambers does the mammalian heart contain, and what are they called?

A

4 chambers

  • right and left atrium
  • right and left ventricle
41
Q

what are the key features of the external structure of the heart?

A
  • off centre in left of chest cavity

- coronary arteries lay over surface

42
Q

what causes angina or heart attacks?

A

if the arteries on the surface of the heart, become restricted, so the heart muscle reduce delivery.

43
Q

what are some details of the internal structure of the heart

A
  • 4 chambers
  • vena cava
  • pulmonary vein
  • aorta
  • pulmonary artery
44
Q

what are the names of the different valves in the heart?

A
  • tricuspid valve + bicuspid valve
  • mitral valve
  • pulmonary/semi-lunar valve
  • aortic valve
45
Q

how do you work out heart rate of the cardiac cycle?

A

heart rate = 60 / cycle time(s)

46
Q

how many stages of the cardiac cycle are there, and what are they called?

A

there are 3 stages

  • atrial systole
  • ventricular systole
  • diastole
47
Q

what is systole?

A

when the heart contracts

48
Q

what is diastole?

A

when the heart relaxes

49
Q

what happens during atrial systole?

A

-atria contracts, which forces small amounts of blood into the relaxed ventricles

50
Q

what happens during ventricular systole?

A
  • ventricular contraction
  • AV valve closes
  • blood is forced out of pulmonary artery and aorta.
  • rise in ventricular pressure, semilunar valves open
51
Q

what happens during diastole?

A
  • ventricles relax, so pressure drops and blood flows back against cusps of sl valves, so they close
  • blood flows into relaxed atria and ventricles
  • as all chambers are relaxed, the ventricles fill passively.
52
Q

when do the ATRIOVENTRICULAR VALVES and SEMILUNAR VALVES open?

A
AV= diastole 
SL= systole
53
Q

when do the ATRIOVENTRICULAR VALVES and SEMILUNAR VALVES close?

A
AV= systole
SL= diastole
54
Q

what is the definition of the cardiac cycle?

A

the sequence of events that make up on single heartbeat.

55
Q

what are the role of valves in the cardiac cycle?

A

to stop backflow of blood

56
Q

what are the pressure changes during the cardiac cycle?

A
systole= contraction so pressure rises
diastole= relaxation, so pressure decreases
57
Q

how do you work out cardiac output?

A

cardiac output = heart rate X stroke volume

58
Q

what is the functions of blood?

A

the transport of

  • co2 and o2
  • digested food from small intestines
  • nitrogenous waste
  • chemical messages
  • platelets to damaged areas
  • cells/antibodies in immune response
59
Q

what part of the blood carries oxygen?

A

red blood cells

60
Q

when does oxygen enter the body?

A

during respiration

61
Q

how does oxygen get to the red blood cell from the plasma in the capillaries?

A

oxygen diffuses across the plasma membrane of the red blood cells into the cytoplasm

62
Q

what does oxygen bind with in the rbc and what does this form?

A

oxygen bind with haemoglobin to form oxyhaemoglobin

63
Q

whats the equation for the oxygen binding with haemoglobin?

A

Hb + 4O2 —> Hb (O2) 4

64
Q

what type of protein is Hb?

A

= a large, globular protein, with 4 peptide chains (each with an iron-containing haem prosthetic group.

65
Q

how many subunits does Hb have?

A

4

66
Q

how many oxygens can each Hb bind to?

A

4

67
Q

what does each subunit in Hb consists of?

A

a polypeptide chain and a haemoglobin (non-protein) group.

-haem group contains single iron atoms

68
Q

what does the iron atom in the haem group do?

A

attracts and holds oxygen molecule, meaning the group has an affinity for oxygen

69
Q

what does the Hb’s ability to take up + release oxygen depend on?

A

the amount of oxygen in the surrounding tissue

70
Q

what is the partial pressure of oxygen / oxygen tension?

A

the pressure that oxygen contributes to a mixture of gases

71
Q

if the amount of oxygen is great, what is partial pressure like?

A

also great

72
Q

what are the axis on the oxygen dissociation graph

A
  • percentage saturation of Hb

- partial pressure of oxygen

73
Q

what is the shape of the line on this OD graph?

A

an S shape

74
Q

what is the conformal change?

A

the adjustments of a proteins tertiary structure in response to external factors.

75
Q

what is positive cooperativity?

A

the effect of the substrate being able to bind to a second subunit

76
Q

what is PC seen as on the curve on the graph?

A

when the curve rises steeply

77
Q

what does a small change in partial pressure cause, to do with oxygen?

A

a large change in the amount of oxygen that haemoglobin carries.

78
Q

why is it difficult to achieve 100% saturation of Hb molecules?

A

it is difficult for the fourth oxygen molecule to diffuse in and associate, due to the other 3 oxygens.

79
Q

when does Hb have increased oxygen affinity?

A

when more oxygen molecules bind to it.

80
Q

what is foetal Hb?

A

a slightly different protein, with a higher affinity to oxygen.

81
Q

what does a higher affinity mean?

A

there is higher partial pressure of oxygen to saturate 50% of Hb.

82
Q

why does foetal Hb have a higher affinity?

A

if affinity was the same as mothers, then little/no oxygen would transfer, as they get their oxygen via the mother’s blood via the placenta.

83
Q

what is the BOHR EFFECT?

A

the change when the partial pressure of CO2 rises, so the Hb gives up oxygen more easily.
the increase in CO2 conc causes a shift in the O2 dissociation curve

84
Q

what happens to the line on the graph due to the BOHR EFFECT?

A

line moves up or down from orginal

85
Q

why is the bohr effect IMPORTANT?

A
  • active respiring tissue have a high PPCO2, so haemoglobin gives up O2 more easily
  • in lungs, CO2 is low, so oxygen binds easily.
86
Q

if the BOHR EFFECT leads to the curve being above the normal line, what does this mean?

A

low CO2, high ph

87
Q

if the BOHR EFFECT leads to the curve being below the normal line, what does this mean?

A

high CO2, low ph

88
Q

what are the 3 ways in which carbon dioxide is transported?

A
  • in aqueous solution in the blood plasma.
  • in combination with haemoglobin.
  • in the form of hydrogen carbonate ions.
89
Q

what enzyme is present within red blood cells?

A

carbonic anhydrase

90
Q

what does the reaction of carbon dioxide and water create in the red blood cell?

A

CARBONIC ACID

H2CO3

91
Q

what does the dissociation reaction of carbonic acid create?

A

hydrogen ions + hydrogencarbonate ions

H+) ( HCO3+

92
Q

when the hydrogen ions form with Hb, what does this form/do?

A
  • forms haemoglobic acid (HHb)

- this then releases the oxygen it is carrying

93
Q

why does Hb act as a buffer?

A
  • it ‘mops up’ H+
  • if H+ was left in blood, then blood would become very acidic
  • this means that it remains at around 7.4 pH
94
Q

what does the reaction that produces hydrogen cause?

A

a decrease in the pH.

95
Q

how much CO2 is carried in the plasma

A

about 5% (dissolved)

96
Q

how much CO2 combines with amino groups to form carbaminohaemoglobin?

A

10-20%

97
Q

how much CO2 converts into hydrogen carbonate ions in RBC?

A

75-85%

98
Q

what is CHLORIDE SHIFT?

A

when the electrical balance of the cell is maintained due to hydrogen carbonate ions moving out of the RBC and chloride ions moving into it.