3.10.14 Autonomics drug flashcards
Amphetamine
Indirect-acting sympathomimetic
Induces release of stored catecholamines
Cocaine
Indirect acting sympathomimetic
Blocks reuptake at the NE and DA transporter
Muscarine toxicity
Toxicity = SLUDGE Salivation Lacrimation Urination Defecation GI upset Emesis
Neostigmine
Cholinesterase inhibitor Postoperative/neurogenic ileus Urinary retention Myasthenia gravis (diagnostic) Alzheimer's disease
Phenylephrine
Alpha agonist
Prazosin
Alpha blocker
Glaucoma
Propanolol
Beta blocker
Cardioselective blocker
Scopolamine
Anti-muscarinic
Anti-motion sickness (dry mouth!!!)
Tyramine
Indirect acting sympathomimetic
What drugs are nicotinic receptor agonists? used for?
Nicotine (smoking cessation)
What drugs are muscarinic receptor agonists? used for?
Muscarine and bethanechol (ileus and urinary retention; glaucoma)
What drugs block muscarinic receptors? used for?
Atropine and scopalamine (motion sickness; cholinergic toxicity; antidiarrheal; dilation of the eyes)
Toxicity of muscarinic antagonists?
Blind as a bat
Dry as a bone
Red as a beat
Mad as a hatter
What drugs are cholinesterase inhibitors? used for?
Neostigmine and organophosphates (Alzheimer disease; diagnosis of mysasthenia gravis; glaucoma
What shouldn’t you use if your pt has glaucoma?
Atropine (reduces outflow)