3.1 RPR Flashcards
A sexually transmitted infection that is caused by one of the member of Spirochaetaceae?
Syphilis
Causative agent for syphilis?
Treponema pallidum
One of the members of Spirochaetaceae that is the agent of yaw?
T. pallidum subspecies pertenue
One of the members of Spirochaetaceae that is cause of nonvenereal endemic syphilis?
T. pallidum subspecies endemicum
One of the members of Spirochaetaceae that is the agent of pinta?
T. pallidum subspecies carateum
Lenght of treponema pallidum?
6 to 20mm
width of T. pallidum?
0.1 - 0.2 mm
How many coils of Treponema pallidum?
6 to 14 coils
Organisms in this family have a natural reservoir such as lake (environment) and can multiply within a living host
T or F
F
This bacteria have no natural reservoir and MUST multiply within a living host
MOT of T. pallidum includes:
Direct contact and Sexual transmission
Direct contact is the primary mode of transmission?
T or F?
F
Sexual transmission is the primary mode of transmission
Treponemes are rapidly destroyed by heat, cold, and drying out
T or F
T
What is the initial lesion during primary stage called?
A painless, solitary lesion characterized by raised and well-defined borders
Chancre
Chancre develops between how many days? What is the average?
10 - 90 days
21 days average
Chancre can be seen on the penis of a woman and in the vagina specifically in the cervix of a man?
T or F
F
…. self-explanatory na ito….
Primary stage last for?
a. 1-4 weeks
b. 10-90 days
c. 1-6 weeks
d. 21 days
c
What will happen if the initial chancre is left untreated?
Systemic dissemination
(25% of this case)
Secondary stage is usually observed about _____ months after primary chancre disappears
1 - 2
This stage is characterized by a lack of clinical symptoms
Latent stage
what individual is an exception to latent stage of syphilis?
a. Pregnant
b. HIV patient
c. Children
d. Elder
a
May pass the disease on the fetus
The 3 major manifestation during teritary syphilis includes:
Cardiovascular disease
_________________
_________________
Gummatous syphilis
Neurosyphilis
Are localized areas of granulomatous inflammation that are most often found on the bones, skin, or subcutanerous tissue?
Gummas
Tertiary syphilis typically occurs most other between _______________ following the secondary stage?
a. 10 -30 years
b. 10 - 30 days
c. 10 - 30 hours
a
This stage consist of symptoms of generalized lymphadenopathy,
malaise, fever, pharyngitis and a rash on the skin and mucuous
membranes?
Secondary stage
This stage may involve CNS
a. Primary
b. Secondary
c. tertiary
Secondary stage
A non-treponemal test that are based on flocculation reaction and a presubptive serologic screening test for syphilis?
Rapid plasma Reagin Test
Serum of a person with syphilis contains a non-specific anti-lipid antibody, this termed as?
Reagin
Fatty substances which are release, combined with the protein from Treponema pallidum to form an antigen which stimulates the body to produce antibodies against both the body’s tissue lipids (non-treponemal) as well as the Treponema pallidum protein (specific or treponemal)
T or F
T
RPR test detects the non-specific antilipid antigen and is referred to as a treponemal test for syphilis
T or F?
F
Non treponemal test
A non-treponemal slide agglutination test for the Quantitative detection of reagins in human serum
T or F?
F
Qualitative
What makes the reaction in RPR test visible?
Charcoal
The known RPR antigen consists of_____,_____,_____ that is bound to charcoal particle
Cardiolipin
lecithin
Cholesterol
NOTE:
If the patient has syphilis, the antilipid antibodies (reagin) in the serum will
cross-react with the known RPR lipid antigens and will give a visible clumping
of the charcoal particles
Plasma and serum can be used as a sample?
T or F?
T
Plasma can be used as a sample provided that sample should be centrifuged to remove fibrin before testing
When plasma is used as a sample, centrifuged is done to remove?
fibrin
Not suitable for testing: Hemolyzed, lipemic and high concentration of bilirubin
T or F
T
RPR test result is reported as?
Reactive or non-reactive
