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Immunosero Lab (Midterm) > 3.1 RPR > Flashcards

3.1 RPR Flashcards

1
Q

A sexually transmitted infection that is caused by one of the member of Spirochaetaceae?

A

Syphilis

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2
Q

Causative agent for syphilis?

A

Treponema pallidum

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3
Q

One of the members of Spirochaetaceae that is the agent of yaw?

A

T. pallidum subspecies pertenue

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4
Q

One of the members of Spirochaetaceae that is cause of nonvenereal endemic syphilis?

A

T. pallidum subspecies endemicum

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5
Q

One of the members of Spirochaetaceae that is the agent of pinta?

A

T. pallidum subspecies carateum

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6
Q

Lenght of treponema pallidum?

A

6 to 20mm

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7
Q

width of T. pallidum?

A

0.1 - 0.2 mm

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8
Q

How many coils of Treponema pallidum?

A

6 to 14 coils

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9
Q

Organisms in this family have a natural reservoir such as lake (environment) and can multiply within a living host

T or F

A

F

This bacteria have no natural reservoir and MUST multiply within a living host

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10
Q

MOT of T. pallidum includes:

Direct contact and Sexual transmission

Direct contact is the primary mode of transmission?

T or F?

A

F

Sexual transmission is the primary mode of transmission

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11
Q

Treponemes are rapidly destroyed by heat, cold, and drying out

T or F

A

T

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12
Q

What is the initial lesion during primary stage called?

A painless, solitary lesion characterized by raised and well-defined borders

A

Chancre

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13
Q

Chancre develops between how many days? What is the average?

A

10 - 90 days

21 days average

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14
Q

Chancre can be seen on the penis of a woman and in the vagina specifically in the cervix of a man?

T or F

A

F

…. self-explanatory na ito….

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15
Q

Primary stage last for?

a. 1-4 weeks
b. 10-90 days
c. 1-6 weeks
d. 21 days

A

c

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16
Q

What will happen if the initial chancre is left untreated?

A

Systemic dissemination

(25% of this case)

17
Q

Secondary stage is usually observed about _____ months after primary chancre disappears

A

1 - 2

18
Q

This stage is characterized by a lack of clinical symptoms

A

Latent stage

19
Q

what individual is an exception to latent stage of syphilis?

a. Pregnant
b. HIV patient
c. Children
d. Elder

A

a

May pass the disease on the fetus

20
Q

The 3 major manifestation during teritary syphilis includes:

Cardiovascular disease
_________________
_________________

A

Gummatous syphilis
Neurosyphilis

21
Q

Are localized areas of granulomatous inflammation that are most often found on the bones, skin, or subcutanerous tissue?

A

Gummas

22
Q

Tertiary syphilis typically occurs most other between _______________ following the secondary stage?

a. 10 -30 years
b. 10 - 30 days
c. 10 - 30 hours

A

a

23
Q

This stage consist of symptoms of generalized lymphadenopathy,
malaise, fever, pharyngitis and a rash on the skin and mucuous
membranes?

A

Secondary stage

24
Q

This stage may involve CNS

a. Primary
b. Secondary
c. tertiary

A

Secondary stage

25
Q

A non-treponemal test that are based on flocculation reaction and a presubptive serologic screening test for syphilis?

A

Rapid plasma Reagin Test

26
Q

Serum of a person with syphilis contains a non-specific anti-lipid antibody, this termed as?

A

Reagin

27
Q

Fatty substances which are release, combined with the protein from Treponema pallidum to form an antigen which stimulates the body to produce antibodies against both the body’s tissue lipids (non-treponemal) as well as the Treponema pallidum protein (specific or treponemal)

T or F

A

T

28
Q

RPR test detects the non-specific antilipid antigen and is referred to as a treponemal test for syphilis

T or F?

A

F

Non treponemal test

29
Q

A non-treponemal slide agglutination test for the Quantitative detection of reagins in human serum

T or F?

A

F

Qualitative

30
Q

What makes the reaction in RPR test visible?

A

Charcoal

31
Q

The known RPR antigen consists of_____,_____,_____ that is bound to charcoal particle

A

Cardiolipin
lecithin
Cholesterol

32
Q

NOTE:

If the patient has syphilis, the antilipid antibodies (reagin) in the serum will
cross-react with the known RPR lipid antigens and will give a visible clumping
of the charcoal particles

A
33
Q

Plasma and serum can be used as a sample?

T or F?

A

T

Plasma can be used as a sample provided that sample should be centrifuged to remove fibrin before testing

34
Q

When plasma is used as a sample, centrifuged is done to remove?

A

fibrin

35
Q

Not suitable for testing: Hemolyzed, lipemic and high concentration of bilirubin

T or F

A

T

36
Q

RPR test result is reported as?

A

Reactive or non-reactive

Immunosero Lab (Midterm) (5 decks)

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