303 - prevention and control of infection. Flashcards
What is pathology?
Study of disease - disease is condition of suffering from illness.
What are many disease caused by?
Contamination of body cells by microscopic living organisms.
What is microbiology?
The study of different microorganisms and how they live/function.
What are pathogens?
Organisms that have capability of producing a disease.
What is a non-pathogen?
Organisms that do not cause disease.
What are the 3 main groups of pathogenic microorganisms?
- Bacteria
- Viruses
- Fungi
What is bacteria?
- Microscopic single cell organism
- Survives as inactive spore when it can’t grow/reproduce.
What is a virus?
Ultramicroscopic organism that lives within cell wall of other organisms.
What is Fungi?
Type of microscopic plant organism that grows across cells and tissues.
What are prions?
- Not living microorganisms
- Type of special infectious protein that can cause disease.
What disease’s has prions caused?
‘Mad cow disease’ and its variant, Creutzfeldt-Jakob disease (CJD).
Types of bacteria, and their shape?
- Cocci: circular microorganism. Colonies in cluster are staphylococci, chains are streptococci.
- Bacilli: rod shaped with pointed ends, rounded end is Lactobacilli.
- Spirochacetes: spiral shaped like helix.
How do you remove risk of bacterial infection on dental instruments?
- Sterilise instruments
- Use once and discard if single use.
What are anaerobic bacteria?
Bacteria in oral cavity that has adapted to exist in low oxygen level - deep in caries or in a pocket.
What are antibiotics taken for?
- To kill bacteria causing severe illness
- Kills some helpful bacteria naturally found in body.
What are bactericidal agents?
Chemicals used to clean externally (work surfaces) to kill bacteria.
What are bacteriostatic agents?
Chemicals used to clean externally, do not kill bacteria but prevent them reproducing and multiplying.
What is Streptococcus mutans?
Initial infective bacterium found in dental caries.
What is Lactobacillus?
Later colonisation of established carious lesion as deeper tooth tissue becomes infected.
What are
- Actinomyces
- P gingivalis,
- Prevotella intermedia
- Treponema denticola
- Fusobacterium nucleatum
- Campylobacter rectus
Periodontal disease, bacterial infection of supporting structure of teeth.
What is staphylococci?
Skin boils and gingival boils, impetigo.
What is Bacillus fusiformis and Borellia vincentii.
ANUG (acute necrotising ulcerative gingivitis) - periodontal infection when OH is poor.
Where do viruses live?
Within cells of other organisms.
What do viruses exist as?
A protein capsule that contains chemicals a virus needs to reproduce.
What is Hepatitis A, B, C?
A various inflammatory liver disease.
What is HPV (human papillomavirus)
Linked to oral cancer
What is Herpes varciella?
Chickenpox, affects area supplied by trigeminal nerve and torso.
What is HIV (human immunodeficiency virus)
AIDS, blood borne and fatal viral infection.
What is herpes zoster?
Shingles, painful blistering skin rash
What is Herpes simplex type 1?
‘cold sores’: blister lesions on lips, highly infectious in initial stage if touched.
What is Epstein-Barr virus?
Glandular fever, swollen lymph glands.
What is paramyxovirus?
Mumps, viral infection of parotid salivary glands.
What is Coxsackievirus?
Hand, foot and mouth disease - painful blistering in oral cavity and palms of hands/soles of feet.
Where do fungi live?
The outer surface of the body like, skin, oral cavity lining, nails and surface of eye.
What is the main fungal infection in dentistry?
Candida Albicans
Appearance of acute oral candidosis (oral thrush)
removable white film, underlying red sore patches on soft tissue of oral cavity.
Chronic oral candidosis (denture stomatitis)
- beneath denture and removable appliance
- reddened, painless area under palatal section of appliance
- Raised moisture level beneath appliance and poor appliance hygiene.
Angular chelitis
Candida infection that involves angles of mouth, appear as localised area of inflamed, cracked skin.
What are the effects of disease on the body?
- infection/inflammation
- ulceration
- oral white/red patches
- formation of cyst
- formation of tumor
- congenital/developmental defect
What are the five signs of inflammation?
- heat
- swelling
- pain
- redness
- loss of function
What is infection?
The invasion of body cells by pathogens resulting in a inflammatory response.
Examples of dentally relevant infections:
- Dental caries
- Periodontal disease
- Herpes simplex
What is stomatitis?
General inflammatory condition affecting oral cavity.
Who is usually affected by stomatitis?
- Elderly and denture wearers
What is an ulcer?
- A shallow break in the skin or mucous membrane
- Leaves a raw, painful circular base that may bleed
Recurrent ulcerations
Affects 20% population, patient may have nutritional deficiencies
Ulceration due to systemic disease
diseases that affect digestive system exhibit oral ulceration
- Crohn’s disease
- Ulcerative colitis
- Coeliac disease
- Inflammatory bowel disease
What are the causes of oral white patches?
Oral candidosis
What is Leukoplakia?
a white patch with no obvious local cause
premalignant
associated with smoking/heavy alcohol intake
What is Erythroplakia?
a red patch on oral mucosa
sinister sign of premalignancy of soft tissue
What is a cyst?
an abnormal sac of fluid within body tissue developed over period of time
Examples of dentally related cysts?
- Dentigerous cyst: around impacted/unerupted tooth
- periapical cyst: around tooth apex
- trauma to minor salivary gland = mucocele
What is a tumour?
a swelling within the body tissue due to uncontrolled and abnormal growth of body cells.
What is a benign tumour?
A swelling that causes no harm other than displace its surrounding structures.
What is a malignant tumour?
A swelling that invades and damages its surrounding structures.
Examples of dentally relevant tumours?
- squamous cell carcinoma
- osteosarcoma of mandible/maxilla
- salivary gland tumours
- lymphoma
What is a congenital/developmental defect?
An inherited condition or genetic mutation that produces illness or condition present at birth.
Examples of dentally relevant defects
- cleft lip/palate
- congenital absence of some teeth (hypodontia)
- defect of tooth formation (amelogenseis imperfecta)
What are the bodies 3 lines of defence against attack by pathogens?
- Skin and mucous membranes are physical barriers
- Surface secretions onto skin or mucous membranes dilute and neutralise the pathogen e.g. saliva, sweat and tears.
- inflammatory response within body tissues if skin/mucous membranes are breached
Who is most likely to suffer when attacked by pathogens and why?
- Elderly: function of body cells not as efficient
- Young children: immune system not functioning fully/not developed acquired immunity to certain pathogens
- Debilitated: immunocompromised patients as they have underlying illness so immune system can’t fight pathogen well.
In the dental workplace, how can pathogen microorganisms breach the skin or mucous membrane and gain entry?
- Direct contact: bodily fluids like saliva, blood, vomit.
- Airborne droplets: sneezing, coughing or spitting.
- Direct entry: damaged skin, or cuts, grazes.
Aerosol spray: created during use of dental handpieces and water sprays - spray blood/saliva into atmosphere. - inoculation injury: piercing of skin with contaminated instrument like needlestick injury.
How does tissue repair after an inflammatory response?
New leucocytes remove damaged/dead tissue and lay temp layer of repair cells.
What is natural immunity?
present from birth by being randomly inherited
What is passive immunity?
present from birth and inherited directly from mothers pool of antibodies/antitoxins
What is acquired immunity?
creation of necessary antibodies/antitoxins by leucocytes during initial pathogen attack. These remain in body for life.
Vaccination to produce acquired immunity
harmless dose of pathogen given to stimulate leucocytes to develop antibodies/antitoxins without actual disease developing.
What is a leuococyte?
white blood cells