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Question 1

What are the cells involved in Chronic Inflamm?

Answer 1

1. MAC
2. Lymphocytes
3. Eosinophils
4. Fibroblasts / Myofibroblasts

Question 2

What is the role of MAC in Chronic Inflamm?

Answer 2

Phagocytosis + Debris/ Bac destruction
Presenting antigen to immune system
Synth of: cytokines / complement components / clotting factors

Question 3

What is the role of Lymphocytes in Chronic Inflamm?

Answer 3

B differentiate ➡️ prod antibodies

T involved w control (CD4) & Cytotoxic functions (CD8)

Question 4

When are Eosinophils seen in Chronic Inflamm?

Answer 4

Allergic reactions
Parasite infections
Tumours

Question 5

What are fibroblasts / myofibroblasts recruited by?

Answer 5

MAC

Question 6

What do fibroblasts / myofibroblasts prod?

Answer 6

Collagen

Question 7

What is a Giant Cell?

Answer 7

Large multinucleated mass formed from the union of different cells
As a result of infection

Question 8

What are the 3 types of Giant Cell, and what are they assoc w?

Answer 8

1. Langhans (TB)
2. Foreign Body Type (Foreign material)
3. Touton (high lipid content)

Question 9

What are the 3 causes of Chronic Inflamm?

Answer 9

1. Take over from acute inflamm (if damage too severe to solve)
2. Alongside acute (severe / persistent / repeated acute)
3. De novo (AI / chronic infections)

Question 10

What are the 4 effects of Chronic Inflamm?

Answer 10

1. Fibrosis (e.g. cirrhosis)
2. Impaired function (increased mucus secretion In hyperthyroidism)
3. Atrophy (e.g. adrenal glands)
4. Immune Response Stim

Question 11

What is a granuloma?

Answer 11

A collection of epithelioid cells (mod. MAC)

Question 12

What do granulomas deal with?

Answer 12

Poorly soluble particles

Organisms difficult to eliminate (e.g. myobacterium TB)

Question 13

What are the 2 causes of a Granulomatous Inflamm?

Answer 13

1. Irritant foreign material (suture material)

2. Infections (myobacterium TB / fungi)