2B : Preventive Pediatrics Flashcards
@ the core of the field of Pediatrics
Preventive Pediatric Health Care
Tasks of preventive pediatric health care
Disease Detection
Disease Prevention
Health Promotion
Anticipatory Guidance
Screening , Surveillance
Disease Detection
○ ANEMIA
what is SURVEILLANCE
what is DETECTION
■ Surveillance: Dietary hx; PE
■ Screening: Hb, Hct
○ DEVELOPMENT
■ Surveillance:
■ Screening:
■ Surveillance: observation
■ Screening: structured developmental tool
○ Fluoridation of water
○ Tetanus immunization
○ Counselling parents about poisons and drugs
primary prevention
avoiding disease before they occur
primary
early identification and treatment before disease progression
SECONDARY
○ Screening programs for scoliosis
○ Lead levels
○ Tx of a Strep infxn w/ antibiotics
secondary
directed @ ameliorating or halting disabilities
tertiary
○ Physical therapy - Cerebral Palsy
○ Chest physiotx - Cystic Fibrosis
tertiary
● Focus on wellness , strengths of the family
Health Promotion & Anticipatory Guidance
Opportunity to help the family address relationship issues; broach on safety topics; access community services
Health Promotion & Anticipatory Guidance
Ultimate goal of immunization:
eradication of disease
Immediate goal of immunization:
prevention of disease
person w/ disease ->
Immune system -> Abs
● Natural active immunization
●part/whole microorgs are introduce–> Abs
Artificial active immunization
Transfer of humoral immunity in the form of Abs
passive immunization
maternal Abs to fetus
● Natural passive immunization
high levels of pathogen or toxin-specific Abs given to non-immune persons
atificial passive immunization
indications of active immunization
- Induce protective immune responses vs. attack of the natural infection
- Once immunized, individual less likely be a source of infection
indications of PASSIVE IMMUNIZATION
●** Congenital/ acquired B-cell defects** alone or in combination w/ other Immunodeficiencies
● When time does not allow protection w/ active immunization alone. (eg. Rabies, Hepatitis B)
● When a person is susceptible and w/ high risk of complications (eg. leukemia)
● (+) Disease : Abs may help in suppressing its toxic effects (eg. tetanus, Kawasaki)
● BCG
● MEASLES
● MMR
LIVE ATTENUATED
● VARICELLA
● ROTAVIRUS
● INFLUENZA (INTRANASAL)
LIVE ATTENUATED
● TYPHOID FEVER(ORAL)
● ORAL POLIO
● DENGUE TETRAVALENT
LIVE ATTENUATED
● YELOW FEVER
● JAPANESE B ENCEPHALITIS
LIVE ATTENUATED
● HEPATITIS B
● DTwP or DTaP or Tdap
● H. influenzae B
INACTIVATED (KILLED)
PNEUMOCOCCAL
HEPATITIS A
MENINGOCOCCAL
INACTIVATED (KILLED)
INFLUENZA
HUMAN PAPILLOMA VIRUS
TYPHOID FEVER
RABIES
INACTIVATED POLIO VIR
INACTIVATED (KILLED)
○ Modified, weakened virus or bacteria
● LIVE Attenuated vaccines
○ Retain the ability to replicate , produce immunity
○ Produce immunologic memory that is similar to that acquired by having the natural dse
LIVE ATTENUATED VACCINES
○ Killed microorgs or inactivated components like toxoids, subunit or subvirion products or cell wall polysaccharides
INACTIVTED VACCINES
○ LESS affected by circulating Abs
○ Produce Humoral IMMUNE RESPONSE
○ Multiple doses needed to BOOST Ab titers
INACTIVATED VACCINES
CLASSIFICATIONS OF VACCINES
* Toxoids, whole cell
* Toxoids , inactivated component
* Toxoids
* Polysaccharide Protein Conjugate
INACTIVATED BACTERIAL
DTwP
classification:
types:
route:
- inactivated bacterial
- Toxoids, whole cell
- IM
DTaP, Tdap
classification:
types:
route:
- inactivated bacterial
- toxoids, inactivated component
- IM
Tetanus, Td
classification:
types:
route:
- inactivated bacterial
- Toxoids
- IM
Hemophilus influenza type B (HIB)
classification:
types:
route:
- inactivated bacterial
- polysaccharide protein conjugate
- IM
Cholera
classification:
types:
route:
- inactivated bacterial
- inactivated whole
- oral
Meningococcal
Typhoid fever
classification:
types:
route:
- inactivated bacterial
- polysaccharides
- IM
Poliovirus (IPV)
Rabies
Hepatitis A
classification:
types:
route:
- inactivated viral
- inactivated virus
- IM
Hepatitis B
classification:
types:
route:
- INACTIVATED VIRAL
- Recombinant subunit
- IM
Influenza
classification:
types:
route:
- inactivated viral
- inactivated viral components
- IM
Human Papilloma Virus
classification:
types:
route:
- inactivated viral
- recombinant viral Ag
- IM
classification:
types:
route:
DTP-base combi:
DTaP-IPV-Hib
DTaP-IPV-Hib-HepB
DTaP-IPV
DTwP-Hib-HepB
- Combination inactivated viral and bacterial
- Toxoids, inactivated bacterial components, recombinant viral Ag, polysaccharide-protein conjugate
- IM
Measles
Measles-Mummps-Rubella (MMR)
Measles-Mumps-Rubella-Varicella (MMRV)
Varicella
Polio virus (OPV)
classification:
types:
route:
- live viral
- live attenuated virus
- SQ
classification:
types:
route:
Bacillus Calmette-Guerin (BCG)
- live bacterial
- live bacteria
- ID
TYPES OF ROUTE FOR INJECTION
- IM - 90 degrees
- Subcutaneous - 45 degrees
- intravenous - 25 degrees
- Intradermal - 10-15 degrees
based on volume of injected material and muscle size
IM
site for IM injection for less than 1 year old
ANTERO-LATERAL THIGH
site for IM injection of more than 1 year old
deltoids
can you inject in Upper, outer buttocks
: A BIG NO, NO!
● SIMULTANEOUS ADMINISTRATION OF MULTIPLE VACCINES
○ Use separate syringes, sites
○ >/ 2 inactivated vaccines or inactivated and live vaccine combinations
Given simultaneously or @ any interval between doses
2 parenteral live vaccines
Given simultaneously or interval of 4 wks
Cholera & Yellow Fever vaccine
(3 wks interval)
● LAPSED IMMUNIZATIONS
○ No need to reinstitute the entire series
○ Subsequent immunizations given in the next visit
● UNKnown/UNCERTAIN IMMUNIZATION STATUS
○ Initiated w/out delay on a sched commensurate with the person’s age
○ NO evidence that giving vaccines to already immune recipients are harmful
contraindications:
Anaphylactic reaction
permanent
contraindications
pregnancy
temporary to live vaccines
contraindications
immunosuppressions
temporary to liove vaccines
contraindications
encephalopathy within 7 days after pertussis vaccination
permanent
Vaccination course given prior to an exposure
pre exposure prophylaxis
Preventive med tx given after exposure to a pathogen
PEP
post exposure prophylaxis
(PrEP)
Preventive med tx given after exposure to a pathogen
PEP
post exposure prophylaxis
NB, w/in the 2 months of life
BCG
TB Meningitis, Disseminated TB
BCG
● Vaccine preparations available for BCG
○ Freeze Dried Glutamate BCG vaccine (Japan)
○ BCG vaccine powder and solvent for suspension for injection
● Dosage & Sched: for BCG
○ Intradermal(ID)
○ < 12 months: 0.05 ml
○> 12 months: 0.10 ml
● Purified Protein Derivative (PPD) prior to BCG vaccination in what conditions
in any of the following:
○ Suspected Congenital TB
○ Hx of close contact to known or suspected infectious cases of TB
○ Clinical findings suggestive of TB and/or CXR suggestive of TB
● Adverse reactions for BCG
○ LAD
○ Abscess injection site
● Normal reaction to BCG vaccination?
○ @ 3 wks
small area of erythema
● Normal reaction to BCG vaccination?
@ 6-10 wks
: raised papule w/ redness
● Normal reaction to BCG vaccination?
@ 14 weeks
shallow ulceration
● Target popn:
○Infants , children 6 weeks and older
○ Susceptible, unvaccinated children, adolescents, adults
DIPHTHERIA-PERTUSSIS-TETANUS (DPT) (EPI)
Causative agents and transmission:
Diphtheria
- Corynebacterium diphtheria
- person-to-person transmission via respiratory droplets
Causative agents and transmission:
Pertussis
- Bordetella pertussis
- respiratory droplets
Causative agents and transmission:
Tetanus
- Clostridium tetani
- Contaminated wounds
general guidelines for
● 6 wks - 6 yo :
DTaP
● DTaP pediatric formulation (diphtheria-tetanus-acellular pertussis)
general guidfelines for
7- 9 yo
Td
● Td w/out pertussis component (diphtheria-tetanus)
general guidelines for
10-64 yo
Tdap (esp w/ close contact w/ infant)
● Tdap reduced Ag formulation
general guidelines for
65 yo
Td ( esp if w/ close contact w/ infant)
● Td w/out pertussis component (diphtheria-tetanus)
dpt PRIMARY 1 dose minimum age
6 weeks
interval for DPT primary 2 dose
4 weeks
interval for DPT primary 3 dose
4 weeks
interval for DPT primary 4 dose
6 months
○ Booster doses DPT
5th dose @ 4-6 yrs of age before school entry
DPT SCHEDULE
Older/Adolescents:
- Incomplete immunization 7-18 yo
I dose of Tdap and Td for the remaining dose
2 doses given 4 wks apart
Unimmunized 7-18 yo
3 dose primary series @ 0,1,6 months w/Tdap (1st dose) ,
Td after
ADVERSE REACTION DPT
○ Local reactions: erythema, tenderness
○ Abscess
SYSTEMIC REACTION DPT
- Fever (less common)
- Arthus-type rxns: exagg rxns 2-8 hrs after injection; extensive painful swelling from shoulder to elbow
- Less frequent: high fever, persistent crying (>3 hrs), hypotonic hypo-responsive episodes (HHE); seizures
- Rarely: gen. Urticaria, anaphylaxis, acute encephalopathy (pertussis vaccine), peripheral neuropathy, GBS ( tetanus vaccine)
TARGET POPULATION FOR HAEMOPHILUS INFLUENZAE TYPE B (Hib)
6wks-5 yo
CHILDREN >5 yo:
FOR HIB
○ Functional or anatomic asplenia
○ Immunodeficiency
○ On immunosuppressants
○ HIV/AIDS
○ Transplant pxs
● Disease prevented: H. influenzae type b infection
○ Acute Otitis Media,
Sinusitis
○ PNM
○ Bacteremia
○ Meningitis
● Transmission for HiB
○ Direct PTP via droplets
○ Autoinoculation
○ Aspiration of AF or direct contact with genitalia during delivery
● Vaccine preparations available for HiB
○ Monovalent PRP-T (Polyribosylribitol PO4-Tetanus toxoid) H. influenzae type b conjugate vaccine
○ Combination vaccine w/ DPT, IPV, Hepatitis B
○ Pentavalent w/ DPT, Hep B
Age @ 1st dose
6 wks-6 mos
primary series?
booster?
- Primary series
3 doses, 1-2 mos apart - Booster
12-15 mos
Age @ 1st dose
7-11 mos
primary series?
booster?
2 doses, 1-2 months apart
booster at 18 mos
Age @ 1st dose
12-59
primary series?
booster?
primary series: 1 dose
booster no
● UNVACCINATED OLDER CHILDREN for HIB
12-14 mos
1 dose ffd by 1 booster dose
● UNVACCINATED OLDER CHILDREN for HIB
15-59 mos
1 dose
● UNVACCINATED OLDER CHILDREN for HIB
> 59 mos
NOT Reco unless w/:
- Functional or anatomic asplenia
- Immunodeficiency On immunosuppressants
- HIV/AIDS
- Transplant pxs
1 dose of Hib only vaccine
● Adverse reactions of HiB
○ Local (MC)
■ Pain, swelling, erythema
● Adverse reactions of HiB
systemic
Fever, irritability, severe allergic rxn (rare)
contraindication for HiB vaccine
- severe anaphylactic rxn;
- mod-severe illness (precaution)