2b. Musculoskeletal Pathophysiology Flashcards
What are some of the genetically determined causes of intrinsic muscle disease?
Congenital Myopathies
Chronic Degeneration e.g. Muscular Dystrophy
Membrane Ion Channel Abnormalitiese e.g. Myotonia
What are some of the acquired causes of intrinsic muscle disease?
Inflammatory Myopathies e.g. Polymyositis
Non-inflammatory Myopathies e.g. Fibromyalgia
Endocrine Myopathies e.g. Cushing Syndrome
Toxic Myopathies e.g. Alcohol
What are some of the symptoms of muscle disease?
muscle weakness/tiredness
delayed relaxation after voluntary contraction
muscle pain
muscle stiffness
What are the different types of arthritis?
Osteoarthritis Rheumatoid arthritis Seronegative spondyloarthropathies Infectious arthritis Crystal induced arthritis
What is arthritis?
This is the swelling or tenderness of a joint
What is a Baker’s Cyst?
A fluid-filled swelling that develops at the back of the knee
What is osteomyelitis?
Inflammation of bone and medullary cavity, usually located in one of the long bones
What type of pathogens cause haematogeneous osteomyelitis?
Monobacterium
What type of pathogens cause contagious osteomyelitis?
Polimicrobials
What is the most common pathogen associated with osteomyelitis in children and newborns?
S. Aureus and Group B Strep
What is the most common cause of osteomyelitis in adults?
S. Aureus
What causes osteomyelitis in the elderly?
Group Negative Bacilli
What pathogen causes infection of open fractures?
S. Aureus and Anaerobic Gram Negative Bacteria
What are the pathogens associated with sickle cell osteomyelitis?
Staphlococcus Aureus and Salmonella sp.
What is Gaucher’s Disease?
This is a genetic condition that leads to a build up of lipids in the liver and spleen.