2a. Dermatological Immunology Flashcards
How do keratinocytes participate in the immune response?
Sense pathogens via cell surface receptors.
Produce antimicrobial peptides to directly kill pathogens
Produce Cytokines and Chemokines.
How do langerhans cells participate in the immune response?
They are antigen presenting cells by processing lipid antigens and microbial fragments to present to effector T cells.
How do T cells in the epidermis and dermis participate in the immune response?
The T cell receptors interact with MHC molecules to allow for antigen detection and T cell activation.
What type of T cells are found in the epidermis?
Mainly CD8+ T cells
What type of T cells are found in the dermis?
CD4+ and CD8+ T cells
What is the function of CD4+ TH1 cells?
Activate macrophages to destroy microorganisms
What is the function of CD4+ TH2 cells?
Help B cells to make antibodies
What is the function of CD8+ Cytotoxic T cells?
Directly kill infected cells
How do dendritic cells in the dermis participate in the immune response?
Secrete cytokines and chemokines during the inflammatory immune response.
What are the different types of dendritic cells present in the dermis?
Dermal dendritic cells - Involved in Ag presenting and cytokine and chemokine release
Plasmacytoid dendritic cells produce INFa and found in diseased skin.
How do macrophages in the dermis participate in the immune response?
Eat Mibrobes
Describe Class 1 MHC…
Found in almost all cells
Present Ag to CD8+ cytotoxic T cells
Present endogenous Ag
Describe Class 2 MHC…
Found on antigen presenting cells
Present to CD4+ TH cells
Present exogenous Ag
Name some conditions that are related to immunology in dermatology…
Psoriasis
Dermatitis
Urticaria
Systemic Lupus Erythematosus
What antibody mediates type 1 hypersensitivity?
IgE
