29 Disturbances of CSF, Hydrocephalus, Pseudotumor Cerebri and Low-Pressure Syndromes

Question 1

Effect of inhalation or retention of CO2, raises blood PCO2, decreases the pH of CSF

Answer 1

Potent cerebral vasodilator, causing an increase in cerebral blood flow and blood volume leading to intracranial hypertension p.640

Question 2

Hyperventilation

Answer 2

Reduces PCO2, increases pH and cerebral vascular resistance and decreases CSF pressure p.640

Question 3

Monroe- Kellie model

Answer 3

The intact cranium, vertebral canal together with the relatively inelastic dura form a rigid container, such that an increase in the volume of any of its content-brain, blood or CSF—will elevate the ICP. p.640

Question 4

Blood brain csf barrier

Answer 4

Endothelium of the choroidal and brain capillaries,
plasma membrane and adventitia (Rouget cells) of these vessels,
pericapillary foot process of astrocytes p.638