272 - Cancer Prevention Flashcards
Chemoprevention for cervical cancer?
HPV vaccine
What patient population would benefit most from cancer prevention treatment?
Population at high risk for cancer
What is the initial step in cancer development?
Genetic mutation
Critical issues about recommendations regarding cancer prevention drugs involve:
a. safety & tolerability
b. efficacy against established tumors
c. demonstration of survival benefit
d. cost.
a. safety & tolerability
Are there any agents approved for cancer prevention in prostate cancer?
No
What is the recommendation for chemoprevention of colon cancer?
- Diet, lifestyle, smoking cessation
- Low dose aspirin only in people age 50-70 who also have CVD risk factors
- 50-59 –> Grade B
- 60-69 –> Grade C (individual decision)
- Not recommended in older people; risk of hemorrhage
What is the recommended agent for breast cancer prevention in:
- Premenopausal women:
- Postmenopausal women:
- Premenopausal women: Tamoxifen (antiestrogenic effects in the breast and estrogenic effects in the uterus and bone)
- Postmenopausal women:
- If uterus intact and osteoporosis: Raloxifene (estrogen antagonist in breast + endometrium and agonist in bone)
- If uterus intact and no osteoporosis: Exemestane (aromatase inhibitor that decreases estrogen production)
The following statements about cancer prevention and treatment are true (pick all that apply):
a. Both employ molecular targeted therapy.
b. Only the effects of cancer treatment can be measured.
c. Risks of not intervening apply only to cancer treatment.
d. Treatment of metastatic cancer cures more patients than can be achieved with cancer prevention
a. Both employ molecular targeted therapy
Aspirin for prevention of colon cancer should be considered in
a. all adults
b. individuals over age 50
c. all individuals at risk for cardiovascular disease
d. those aged 50-70 who have an increased risk of cardiovascular disease.
d. those aged 50-70 who have an increased risk of cardiovascular disease.
Don’t use in everyone
