27 CNS stimulation (drugs)

Question 1

CNS stimulant

what drug blocks adenosine recptors?

Answer 1

caffeine

Question 2

what drug is a an inhibitor of the reuptake of

norepinephrine, dopamine and serotonin

and

its receptor on the transporter for dopamine competes for binding

of the endogenous ligand resulting in increased ligand in the synapse

and

increases

tyrosine and tryptophan hydroxylase

and

Local anesthetic; vasoconstrictor

Answer 2

cocaine

Question 3

what drug?

Mechanisms of action

Releases norepinephrine, dopamine and serotonin

Blocks transmitter uptake into presynaptic terminals (like cocaine)

Direct partial agonist of alpha-adrenergic receptors

MAO inhibition (at high doses)

Answer 3

amphetamine

Question 4

what amphetamine has

better CNS bioavailability, more CNS effect,

higher abuse liability

Answer 4

methamphetamine

Question 5

what drug is

not actually an amphetamine but structurally and mechanistically very similar

Answer 5

methylphenidate

Question 6

what drug is used to treat narcolepsy?

Answer 6

amphetamine

Question 7

what drug is used to treat ADHD?

Answer 7

Amphetamine, methylphenidate

• Excessive motor activity, racing thoughts, difficulty in

sustained attention; academic underachievement

Question 8

what drug is an agonist of nicotinic cholenergic receptors?

in the autonoic ganglia

Sympathetic ganglia activation results in release of epinephrine

• Parasympathetic ganglia activation is predominant; results in GI effects (nausea; increased motility)

in the CNS: causes membrane depolarization.

Answer 8

nicotine

Question 9

what drug is for the treatment of nicotine dependance?

mech

Mechanism of action - unknown, seems to enhance noradrenergic

and dopaminergic signaling

Answer 9

Bupropion

Question 10

what drug helps with nicotine dependance by

• Activates nicotinic receptors alone enough to reduce craving and withdrawal
• Reduces the effects of the full agonist, nicotine

Answer 10

Varenicline