25b antimania antianxiety hypnotic muscle relaxants. Flashcards
what is the drug fro treament of bipolor disorder?
lithium
not bound to plasma
what is teh mech of action for lithium?
blocks the conversion of IP2 to IP1
what things effects the level of lithium in the body?
the more Na that is excreted the more lithium is in the body.
what is a first line antimania drug that causes sedation?
what does it do in the body?
valproic acid (divalproex)
increases GABA and decreases Ca content.
what is a anti mania agent that blocks Na channels?
carbamazepine
has some CNs side effects.
what are 2 agonists of the benzodiazapine?
diazepam
zolpidem
what is a benzodiazapine antagonist?
flumazenil
what does binding to the GABA receptor increase the level of intracellularyl?
Cl
increases Cl conductance.
what is a partial agonist for 5-HT1A? that blocks adenylate cyclase and opens K channel.
used for the treatment of anxiety?
BUSPIRONE
not a benzo
binds to dopamine channels too.
what do you use for benzodiazapine withdrawls?
gradullay lower dose.
use a long acting medication.
what is a benzo that is also used as a muscle relaxer? and for sedation with a long duration.
DIAZEPAM
what benzo is used for panic disorder? and is a short duration
alprazolam
what 2 benzos are used for sleep
lorazepam
flurazepam
what is a non benzo for sleep that still binds to the benzo receptor?
what is an antagonist for it?
zolpidem
flumazenil
what is a barbiturate?
pentobarbital - for sleep
chloral hydrate -meatabolized to active form.
