25a antidepressants and antipsychotics

Question 1

where is seratonin from

Answer 1

raphe nuclei

Question 2

where is norephinepherine from?

Answer 2

the locus coeruleus

Question 3

what is the mesolimbic dopamine?

Answer 3

from the sustantia nigra

goes to the caudate putamen and nucleaus acumbans.

Question 4

what is the mesocortical dopamine

Answer 4

from the vental tegmental areas

to the prefrontal cortex.

Question 5

where is the GABA localized to?

Answer 5

substanita nigra globus paladus and hippocamus

and the limbic system amgydala hypothalmus and spinal cord.

Question 6

what is a tricyclic antidepressant for chronic pain?

Answer 6

amitriptyline

Question 7

what is a tricyclic antidepressant for OCD?

Answer 7

clomipramine

Question 8

what is the SSRI with a long half life?

Answer 8

fluoxetine

Question 9

whta is the SSRI with a shorter half life? and less effect on drug metabolism

Answer 9

sertraline

Question 10

what is an atypical antidepressant that is used form SAD and nicotine withdrawl?
blocking NE and dopamine uptake

Answer 10

BUPROPION

Question 11

what is the atypical antidepressant that is used to increase apitie?
what does it blcok?

Answer 11

MIRTAZAPINE

blocks presynaptic alpha 2 in the brain .

Question 12

what is phenelzine?

what is a use for it?

Answer 12

it is a MAO inhibitor. irreversible for MAO-A

used for the treatment of narcolepsy

Question 13

what is the problem with MAOI and eating cheese or sausage

Answer 13

they have tyramine in them and usually tyramine is broken down in the liver. but if you give MAOI it isnt.
this allows the tyramine to get into the blood stream and can effect the heart causing a hypertensive crisis.

Question 14

what area of the brain is associated with the positive symptoms of schizophrenia?

Answer 14

lots of dopmamine in the limbic area.

Question 15

what do D1 receptors do?

Answer 15

they they activate the adenylate cyclase. Gs

Question 16

what do D2 receptors do?

Answer 16

they inhibit the adenylate cyclase. D2,3,4 Gi

Question 17

what receptors do the atypical antipsychotic drugs act on?

Answer 17

D receptors
and
5-HT2 in the forebrain.

Question 18

what are extrapyramidal side effects of some antipsychotic drugs?

Answer 18

dystonias and parkinsons early on.

later can have tardive dyskineasia. like a tic, lip smacking.

Question 19

what is a typical drug that is used? with low potency and some anticholengeric effects.

Answer 19

chlorpromazine

Question 20

what is a typical drug that is used? with low potency and some anticholengeric effects. and some cardiac effects?

Answer 20

thioridazine

Question 21

what typical drugs is used that has high potency and less sedative and cholenergic effects?

Answer 21

fluphenazine

Question 22

not chemically related to the phenothiazines but is

pharmacologically similar to the high-potency piperazine derivatives.

Answer 22

haloperidol

Question 23

what is the better about the sideeffects of the atypical ?

Answer 23

less extrapyramidal effects.

Question 24

what atypical blocks D4 and 5-HT2?

what are some side effects?

Answer 24

clozapine

there is some weight gain and acute granulocytosis

Question 25

what atypical is more of a 5-HT2 blocker with diabetes risk and no agranulocytosis

Answer 25

olanzapine

Question 26

what is a combined D2 and 5-HT2 antagonist and better reduction of the negative sympotoms.

Answer 26

risperidone

Question 27

what atypical antipsychotic drugs are used as an adjunct in treatment of depression?

Answer 27

quetiapine

aripiprazole

Question 28

what atypical is a partial D2 agonist and 5-HT2 antagonist?

Answer 28

aripiprazole

it is used as an adjunct for depression treatment.

Question 29

what atypical is like clozapine but better?

Answer 29

quetiapine