26-27

Question 1

A 1 receptor location and action

Answer 1

Vascular smooth muscle
Vasoconstriction

Question 2

A 2 receptor location and action

Answer 2

Presynaptic neurons
Action
Na release
Ach release
Insulin releas

Question 3

Drugs blocking receptors Decrease or increase blood pressure?

Answer 3

Dec

Question 4

Alpha have limited clinical applications because

Answer 4

Decrease blood pressure by the effect of alpha blockers induces a reflex tachycardia

Question 5

Phenoxybenzamine is a

Answer 5

nonselective sympatholytic, linking covalently to both α1and α2 receptors

Question 6

Phenoxybenzamine block is

Answer 6

irreversible

Question 7

the only way the body can overcome
the Phenoxybenzamine block is to

Answer 7

synthesize new adrenoceptors

Question 8

Phenoxybenzamine actions last about

Answer 8

24 hours.

Question 9

Actions of phenoxybenzamine

Answer 9

Cardiovascular effects:
decreased blood pressure provokes a reflex
tachycardia

Question 10

Therapeutic uses of Phenoxybenzamine

Answer 10

treatment of pheochromocytoma
treating Raynaud disease and frostbite

Question 11

Adverse effects of phenoxybenzamine

Answer 11

1. postural hypotension
2. reflex tachycardia

Question 12

Phentolamine Mechanism of action

Answer 12

competitive ( reversible) blocker of α1 and α2 receptors

Question 13

Phentolamine Pharmacological actions

Answer 13

it produces postural hypotension
reflex cardiac stimulation and tachycardia

Question 14

Phentolamine Therapeutic uses

Answer 14

management of pheochromocytoma.

Question 15

Phentolamine can be administered by

Answer 15

intravenous or intramuscular route

Question 16

Phentolamine half life is

Answer 16

short half-life, 19 min after intravenous administration

Question 17

Prazosin, terazosin Mechanism of action

Answer 17

selective competitive blockers of the α1
receptor

Question 18

Prazosin, terazosin Therapeutic uses

Answer 18

treatment of hypertension.

Question 19

Prazosin, terazosin Adverse effects

Answer 19

dizziness, a lack of energy, headache,
drowsiness, and orthostatic hypotension,
Tachycardia

Question 20

Tamsulosin mechanism

Answer 20

selective α1 antagonists

Question 21

Tamsulosin uses

Answer 21

treatment of benign prostatic
hyperplasia
Blockade of the α1A receptors
decreases tone in the smooth
muscle of the bladder neck and
prostate and improves urine flow.