24/25 Flashcards
Amphetamine effects
Central nervous system stimulant
1. increase release of catecholamines from nerve terminals)
2. Inhibit monoamine oxidase (MAO)
3. Inhibit catecholamine reuptake
an indirect-acting adrenergic drugs
Amphetamine
Cocaine
Therapeutic uses of amphetamine
- Attention deficit hyperactivity disorder (ADHD)
- Narcolepsy
- Appetite suppression
Methylphenidate
is a central nervous system (CNS) stimulant medication used to treat
(ADHD) and, to a lesser extent, narcolepsy
What is a primary medication for ADHD
Methylphenidate
Phentermine IS used to treat
obesity
Amphetamine Adverse effects
- Central nervous system effects: (Addiction, insomnia, irritability, tremor, and hyperactive reflexes, weakness, confusion, dizziness , delirium, panic states) amphetamine psychosis, schizophrenia 2. Cardiovascular effects: palpitations, cardiac arrhythmias, hypertension and
anginal pain. 3. Gastrointestinal system effects: anorexia, nausea, vomiting, abdominal
cramps, and diarrhea.
Amphetamine Contraindications
- Patients with hypertension, cardiovascular disease,
hyperthyroidism, glaucoma, or a history of drug abuse - Patients taking MAO inhibitors should not be treated with amphetamine.
Cocaine mechanism is indirect by
block the cellular uptake of norepinephrine into the
adrenergic neuron
Tyramine is found in
fermented foods, (such as aged cheese)
mixed-action non-selective adrenergic agents
Ephedrine and pseudoephedrine
Ephedrine and pseudoephedrine release what? Stimulates what?
- They release stored norepinephrine
from nerve endings - And stimulate both α and β receptors.
Therapeutic uses of Pseudoephedrine:
Used to treat nasal and sinus congestion (orally)
Raise bp