258 revision Flashcards
what’s the difference between bactericidal and bacteriostatic?
one actually kills bacteria, the other slows there growth enough to render them harmless
what is therapeutic range?
the concentration at which drugs have their desired therapeutic effect
what are the three common gram positive microorganisms
staphylococcus, streptococcus and clostridium
what are the mechanisms of action of antibiotics?
- disruption of cell membrane function
- inhibition of cell wall synthesis
- inhibit dna and rna synthesis
- impact protein synthesis by ribosomes
- inhibit folic acid metabolism
what’s the mechanism of action of penicillin and cephalosporins?
cell wall destruction
how is antibiotic dosage calculated in paeds?
based on weight
which antibiotics will need drug plasma concentrations monitored?
gentamicin, tobramycin, vancomycin
what is important to note about antibiotic therapy in paeds?
cultures should be taken before initiating therapy and continued until infection is no longer present
what are macrolides?
class of antibiotics that inhibit rna synthesis
used to treat respiratory/ENT infections
give two examples of macrolides
erythromycin and roxithromycin
adverse reactions of macrolides
nausea and vomiting
abdo pain
rash
anaphylaxis
what are cephalosporins?
class of antibiotics that inhibit cell wall synthesis
used for gram positive and some gram negative bacteria
how many generations of cephalosporins are there?
four
adverse reactions to cephalosporins?
impaired vitamin K
high sodium
two examples of cephalosporins?
cephazolin
cephalexin
what were the first broad spectrum antibiotics developed?
tetracyclines
give an example of a bacteriostatic antibiotic
tetracyclines
what are tetracyclines?
antibiotics that inhibit protein synthesis
what are three examples of tetracyclines?
tetracycline
doxycycline
tigercycline
what are aminoglycasides?
antibiotics that bind to ribosomes and inhibit protein synthesis
three examples of aminoglycasides?
gentamycin, neomycin, tobramycin
adverse effects of aminoglycasides?
ototoxicity
what is gentamycin used to treat?
- Serious or life threatening conditions
- When other agents are not appropriate
- Gram neg. infections
- Surgical prophylaxis
- Eye infections
what are the adverse effects of gentamycin?
Nephrotoxicity
Vestibular ototoxicity
Use with caution with the elderly
how is gentamycin adminstered?
parenterally
what are penicillins and what do they treat?
antibiotics that inhibit cell wall synthesis
used to treat respiratory infections, UTIs and systemic infections
adverse reactions to penicillins
GI upset, nausea and vomiting
examples of penicillins
- amoxycillin
- ampicillin
- benzylpenicillin
- flucloxacillin
- procaine penicillin
which types of surgery are associated with prophylactic use of antibiotics?
- Joint replacement
- Bowel
- Head and neck
- Dental or oral
- Emergency
- Trauma
- Cardiac
also in people with compromised immune systems
how can nurses help to prevent antibiotic resistance?
Educate our patients to • Take as prescribed • Complete the prescribed doses • Throw away unused antibiotics • Do not share antibiotics • Antiseptic use • Correct medication preparation
what is ototoxicity?
toxicity to the ear - the cochlea, the auditory nerve and sometimes the vestibular system
what are the clinical manifestations of T2DM?
polyuria (excessive urination) glycosuria (glucose in urine) blurred vision polydipsia (excessive thirst) polyphagia (excessive appetite)
what are the advantages of PCA pumps for analgesua?
patients usually require less medication but have better pain relief
how is risk of overdose managed with a PCA?
lockout period