25- Treatment of Hyperlipidemias

Question 1

disorder of lipid and lipoprtn absorption and synthesis

Answer 1

dyslipidemia

Question 2

HDL and LDLs are associated with _______. Triglycerides are associated with ________.

Answer 2

cholesterols

fatty acids

Question 3

what is cholesterol used for?

Answer 3

membranes

sex hormones

Question 4

secure, efficient transport =

Answer 4

HDL

Question 5

insecure, inefficient transport =

Answer 5

LDL

Question 6

calorie transport to and from liver

Answer 6

triglycerides

Question 7

triglycerides are generally ______ proportional to HDL

Answer 7

inversely

Question 8

____ levels directly relate to ASCVD risk

Answer 8

LDL levels

prior this statement would have said total cholesterol

Question 9

atheromas of atherosclerosis contain

Answer 9

cholesterol

Question 10

dyslipidemias have a _______ relationship iwth CAD

Answer 10

causal

there is a clear benefit for lowering serum cholesterol

Question 11

what is the leading cause of death in the US

Answer 11

heart disease for both men and women

Question 12

3 “risk equivalents” which are classified the same as having CAD

Answer 12

DM
known PAD, AAD, etc
chronic renal disease

Question 13

primary correlates with

Answer 13

prevention

Question 14

reasonable lipid screening parameters

Answer 14

20-79 free from CAD
with risk factors
every 4-6 yrs calculate 10 yr risk

Question 15

drug of choice for dyslipidemia management

Answer 15

HMG-CoA inhibitors aka STATINS

Question 16

who could benefit from statin treatment?

Answer 16

1. secondary prevention (all individuals with clinical CVD)
2. isolated LDL severely elevated
3. DM 40-75, LDL elevated
4. 10 yr CVD risk > 7.5%, age 40-75 and LDL elevated

Question 17

LDL lowering drug of choice

Answer 17

statins

Question 18

LDL score of 200 v. LDL score 120

Answer 18

high intensity statin v. moderate intensity statin treatment

Question 19

major side effects of statins

Answer 19

myopathy and increased liver enzymes

Question 20

what is a negative side effect of using bile acid sequestrants to reduce LDL levels?

Answer 20

they may increase TG

also GI distress/constipation and decreased absorption of other drugs

Question 21

which LDL lowering drug class has flushing as a side effect

Answer 21

nicotinic acid

Question 22

what drug might you want to use for someone with known ASCVD or familial hyperchoelsteremia

Answer 22

a PCSK9
proprtn convertase subtilisin kexin type 9

decreases liver LDL receptors

Question 23

true or false: intensity of therapy parallels risk more than lipid levels

Answer 23

true