20- Vasculopathies

Question 1

affects nordics over 50 specifically in the arteries of the head

Answer 1

temporal (giant cell) arteritis

Question 2

pathology of temporal (giant cell) arteritis

Answer 2

granulomatous inflammation (HLA-DR associated) and T-cell mediated

Question 3

“pulseless disease”

Answer 3

takayasu arteritis

Question 4

granulomatous vasculitis of medium and large arteries (esp. arotic archand branches) also pulmonary, coronary, and renal arteries predominantly females under age 40

Answer 4

takayasu arteritis

Question 5

characterized by ocular disturbances and weakening of pulses in upper extremities

Answer 5

takayasu arteritis

Question 6

systemic necrotizing vasculitis of small and medium-sized arteries producing infarcts

Answer 6

polyarteritis nodosa PAN

Question 7

pathology of polyarteritis nodosa

Answer 7

type III immune injury involving immune complexes (associated with he B and C)

Question 8

is there pulmonary involvement with polarteritis nodosa?

Answer 8

no

Question 9

observe beaded appearance of renal a. and melena

Answer 9

polyarteritis nodosa

Question 10

afflicting asian infants, skin rash and peeling with coronary a. aneurysm

Answer 10

kawasaki disease

aka mucocutaneous lymph node syndrome

Question 11

kawasaki disease diagnostic criteria

Answer 11

fever greater than 5 days and 4/5 CREAM

conjunctiviits
rash
edema
adenopathy
mucosal involvement

Question 12

saddle nose disfigurement and granuloma lesions in lung tissue

Answer 12

granulomatosis with polyangitis

aka
Wegener

Question 13

triad of symptoms for granulomatosis with polyangitis

Answer 13

1. necrotizing granulomas of upper respiratory tract
2. granulomatous vasculitis of medium and small vessels
3. necrotizing often crescentic glomerulonephritis

Question 14

PR3 ANCA+ 95% cases

Answer 14

wgener’s granulomatosis

Question 15

MPO-ANCA + 50% cases

Answer 15

churg-strauss syndrome

Question 16

small vessel necrotizing vasculits associated with asthma, allergic rhinitis and lung infiltrates

Answer 16

churg strauss sndrome

Question 17

pahtology of churg-strauss syndrome

Answer 17

peripheral hypereosinophilia and extravascular necrotizing granulomata

Question 18

vascular insufficiency of tibial and radial arteries due to thrommbosing acute and chronic inflammation

Answer 18

buerger’s disease

aka thromboangiitis obliterans

Question 19

caused by hypersensitivity to tobacco

Answer 19

buerger’s disease

aka thromboangiitis obliterans

Question 20

what do SLE, RA, henoch-schonlein purpura and cryoglobulinemia all have in common?

Answer 20

immune complex mediated vasculitides

Question 21

localized abnormal dilation of any vessel

Answer 21

aneurysm

Question 22

vessel most affected by aneurysms

Answer 22

aorta

Question 23

true v. false aneurysm

Answer 23

t: retains all three layers of vessel wall at affected site
f: intima and media damaged, only adventitia remains

Question 24

aneurysm on one side only

Answer 24

saccular

fusiform is the term for the entire vessel aneurysm

Question 25

type of aneurysm typically between renal arteries and bifurcation

Answer 25

atherosclerotic aneurysm

Question 26

type of aneurysm typically at thoracic aorta and arch, a manifestation of tertiary syphillis

Answer 26

syphilitic aneurysm

Question 27

false aneurysm from inflammatory damage

Answer 27

infective aneurysm aka mycotic aneurysm

Question 28

congenital aneurysm in the circle of willis

Answer 28

berry aneurysm

Question 29

false channel of blood coursing within vessel wall itself

Answer 29

aortic dissection

Question 30

disruption and fragmentation of elastic lamellae of the arterial media

Answer 30

cystic medial necrosis

Question 31

malformations present frombirth composed of dilated capillaries and veins in skin and oral cavity

Answer 31

herediatry hemorrhagic telangiectasia

Question 32

radiating subcutaneous arteries ofter associated with cirrhosis of liver

Answer 32

spider telaniectasia

Question 33

painful tumor under firgertips or toenails

Answer 33

glomus tumor aka glomangioma

Question 34

low grade malignant tumor of blood vessel

Answer 34

hemangioendothelioma

Question 35

malignant tumor of blood vessels from pericytes

Answer 35

hemangiopericytoma

Question 36

malignant tumor of blood vessel from carcinogen exposure

Answer 36

angiosarcoma

Question 37

red-purple macules on the skin associated with herpes virus type 8

Answer 37

kaposi's sarcoma

Question 38

red, purple, or blue edematous soft tissue lesions that are caused by ricketssiae like organisms

Answer 38

bacillary angiomas

Question 39

4 complications of varicose veins

Answer 39

- phlebitis - varicose eczema - DVT - leg ulcers