20- Vasculopathies Flashcards
affects nordics over 50 specifically in the arteries of the head
temporal (giant cell) arteritis
pathology of temporal (giant cell) arteritis
granulomatous inflammation (HLA-DR associated) and T-cell mediated
“pulseless disease”
takayasu arteritis
granulomatous vasculitis of medium and large arteries (esp. arotic archand branches) also pulmonary, coronary, and renal arteries predominantly females under age 40
takayasu arteritis
characterized by ocular disturbances and weakening of pulses in upper extremities
takayasu arteritis
systemic necrotizing vasculitis of small and medium-sized arteries producing infarcts
polyarteritis nodosa PAN
pathology of polyarteritis nodosa
type III immune injury involving immune complexes (associated with he B and C)
is there pulmonary involvement with polarteritis nodosa?
no
observe beaded appearance of renal a. and melena
polyarteritis nodosa
afflicting asian infants, skin rash and peeling with coronary a. aneurysm
kawasaki disease
aka mucocutaneous lymph node syndrome
kawasaki disease diagnostic criteria
fever greater than 5 days and 4/5 CREAM
conjunctiviits rash edema adenopathy mucosal involvement
saddle nose disfigurement and granuloma lesions in lung tissue
granulomatosis with polyangitis
aka
Wegener
triad of symptoms for granulomatosis with polyangitis
- necrotizing granulomas of upper respiratory tract
- granulomatous vasculitis of medium and small vessels
- necrotizing often crescentic glomerulonephritis
PR3 ANCA+ 95% cases
wgener’s granulomatosis
MPO-ANCA + 50% cases
churg-strauss syndrome
small vessel necrotizing vasculits associated with asthma, allergic rhinitis and lung infiltrates
churg strauss sndrome
pahtology of churg-strauss syndrome
peripheral hypereosinophilia and extravascular necrotizing granulomata
vascular insufficiency of tibial and radial arteries due to thrommbosing acute and chronic inflammation
buerger’s disease
aka thromboangiitis obliterans
caused by hypersensitivity to tobacco
buerger’s disease
aka thromboangiitis obliterans
what do SLE, RA, henoch-schonlein purpura and cryoglobulinemia all have in common?
immune complex mediated vasculitides
localized abnormal dilation of any vessel
aneurysm
vessel most affected by aneurysms
aorta
true v. false aneurysm
t: retains all three layers of vessel wall at affected site
f: intima and media damaged, only adventitia remains
aneurysm on one side only
saccular
fusiform is the term for the entire vessel aneurysm
type of aneurysm typically between renal arteries and bifurcation
atherosclerotic aneurysm
type of aneurysm typically at thoracic aorta and arch, a manifestation of tertiary syphillis
syphilitic aneurysm
false aneurysm from inflammatory damage
infective aneurysm aka mycotic aneurysm
congenital aneurysm in the circle of willis
berry aneurysm
false channel of blood coursing within vessel wall itself
aortic dissection
disruption and fragmentation of elastic lamellae of the arterial media
cystic medial necrosis
malformations present frombirth composed of dilated capillaries and veins in skin and oral cavity
herediatry hemorrhagic telangiectasia
radiating subcutaneous arteries ofter associated with cirrhosis of liver
spider telaniectasia
painful tumor under firgertips or toenails
glomus tumor aka glomangioma
low grade malignant tumor of blood vessel
hemangioendothelioma
malignant tumor of blood vessels from pericytes
hemangiopericytoma
malignant tumor of blood vessel from carcinogen exposure
angiosarcoma
red-purple macules on the skin associated with herpes virus type 8
kaposi’s sarcoma
red, purple, or blue edematous soft tissue lesions that are caused by ricketssiae like organisms
bacillary angiomas
4 complications of varicose veins
- phlebitis
- varicose eczema
- DVT
- leg ulcers
