22- Acute MI Thrombolytic Therapy

Question 1

prevention is to ________ as treatment is to ______

Answer 1

anticoagulation

thrombolysis

Question 2

3 drugs to prevent formation and growth of clots

Answer 2

• warfarin
• ASA
• NOACs

Question 3

native agent for the breakdown of already formed clots

Answer 3

plasmin

Question 4

how do thombolytics help breakdown clots

Answer 4

by activating plasmin

Question 5

how does streptokinase work?

Answer 5

direct plasminogen activator

Question 6

which thrombolytic contains plasminogen waiting to be activated?

Answer 6

APSAC

“anisolyated plasminogen-streptokinase activator complex”

Question 7

how does urokinase work?

Answer 7

direct plasminogen activator

Question 8

benefit of urokinase vs. APSAC

Answer 8

urokinase is non-antigenic because it comes from human neonatal kidney cells

Question 9

how does alteplase work?

Answer 9

tissue plasminogen activator

Question 10

TIMI grading tells you what?

Answer 10

blood flow in infarct vessel
and risk

high TIMI flow = better

high TIMI risk = worse

Question 11

risk factors for intracranial bleeds with lytics

Answer 11

• > 65 yo
• weight > 79 kg
• HTN
• use of tPA

Question 12

at what point past MI beginning is the treatment shifted from anticoagulants to thrombolysis?

Answer 12

120 minutes

Question 13

what drug is recommended after 120 minutes of MI?

Answer 13

TNKase for thrombolysis