19- Cholesterol and Triglycerides

Question 1

fat is present as ______ in adipose tissue

Answer 1

triacylglycerol

Question 2

___ releases FFA into blood from adipose cell surface

Answer 2

HSL hormone-sensitive lipase

Question 3

HSL is inhibited by ____

Answer 3

insulin

we aren’t releasing FFA in well fed state

Question 4

FFA in the blood bind to ____

Answer 4

albumin

Question 5

“well fed state lipids”

Answer 5

lipoprtns

Question 6

for transport of dietary lipids

Answer 6

chylomicrons

Question 7

for transport of endogenous lipids

Answer 7

VLDL

Question 8

for reverse lipid transport/excretion

Answer 8

HDL

Question 9

entry apoprtn

Answer 9

ApoA

Question 10

structural support Apoprtn

Answer 10

ApoB

Question 11

exit Apoprtn

Answer 11

ApoC

Question 12

interaction w/ receptors apoprtn

Answer 12

ApoE

Question 13

activators of LCAT. Extract lipids from membranes for reverse transport

Answer 13

ApoA

Question 14

structural prtns, interact with lipoprtn receptors and mediate the uptake of particle into target cells

Answer 14

ApoB

Question 15

Modulate lipoprtn lipase activitiy, liberate FFA and glycerol from lipoprtns

Answer 15

ApoC

Question 16

bind to receptors to allow removal of remnant particles from the circulation

Answer 16

ApoE

Question 17

what happens when there is too much LDL in the system..

Answer 17

LDL is bound by cells that are not normally part of the system such as macrophages –? upatke oxidized LDLs leading to plaques and atherosclerosis (foam cells)

Question 18

how is cholesterol added to VLDLs to make them IDL

Answer 18

via CETP the CE jump from HDL to the VLDL

Question 19

Friedewald Formula

Answer 19

LDL cholesterol calculation

LDL = total cholesterol - HDL - 20% triglycerides

Question 20

type I dyslipidemia

Answer 20

increase chylomicrons
increased cholesterol
and increased triglycerides

Question 21

increased LDL and increased cholesterol and NO increased triglycerides

Answer 21

type IIa dyslipidemia

Question 22

increased VLDL and LDL and increased cholesterol and triglycerides

Answer 22

type IIb dyslipidemia

Question 23

increased IDL and cholesterol and triglycerides

Answer 23

type III dyslipidemia

Question 24

increased VLDL and tiglycerides but no increased cholesterol

Answer 24

type IV dyslipidemia

Question 25

type V dyslipidemia

Answer 25

incrased VLDL and chylomicrons and cholesterol and tiglycerides

Question 26

defect in lipoprtn metabolism itself

Answer 26

primary dyslipidemia

Question 27

familial hypercholesterolemia

Answer 27

• defects in ApoE/B LDL receptor
• autosomal codominant
• dyslipidemia IIa or IIb

Question 28

Familial defective ApoB100

Answer 28

defective ApoB100 prevents binding of LDL to receptor

Question 29

disturbance in lipid profile with no actual changes in metabolism

Answer 29

secondary dyslipidemia