25- Eicosanoids

Question 1

What eiconsanoids are pro-inflamatory

Answer 1

omega 6

Question 2

what eiconsaoids are anti-infalmatory

Answer 2

omega 3

Question 3

What are the two major type of eicosanoids:

Answer 3

Leukotrienes and Protanoids

Question 4

What are the derivatival pre-cursors to make eicosanoids?

Answer 4

Needs EPA , AA and DGLA

Question 5

What does the synthesis pathway of a eicosanoids look like?

Answer 5

Need phospholipid membrane that then uses the AA, and if you have activation of COX gene then it makes the protanoids, (which is where meds like NSAIDS/ASPIRIN block at the COX genes to inhibit prostaglandin response)

Question 6

What is the relation with Leukotrienes and aspiring etc?

Answer 6

Leukotriene production , also produces histamins and prostaglandins .. aka inflamatory response and pain

Question 7

What does the leukotriene do?

Answer 7

1) Contract smooth muscles in lungs - allergic response causer
2) Stimulated vascular permeability
3) Act. Leukocytes

Question 8

How do we name prostalandins

Answer 8

Name them by using the chemical structure… ex: ProstA- has a = ring in posit 11..

Question 9

what type of prostaglandins are vassodepressors?

Answer 9

A B C

Question 10

What type of signalling does prostacyclin involve?

Answer 10

Paracrine G-protein coupled R in platelet and endothelical cell cascades

Question 11

What is the consequnece of activating prostacyclins

Answer 11

cAMP lvl increase .. causing vasodilation and inc. permeability

Question 12

What is the definition of a growth factor?

Answer 12

Its any protein stimulating the division and differentiation of specific types of cells

Question 13

where is FGF found in?

Answer 13

Bone

Question 14

What are the 3 interferons

Answer 14

INF-alpha
INF-Beta
INF-gama