19 - Thyroid Flashcards
what hormones are secreted by the Thyroid gland?
Thyroxine and Triiodotyronin
t4 and t3
What secretes calcitonin
the C-cells of the thyroid gland
Iodine deficiency cause defficits in
T4
Through what system does thyroid hormone transport idodes ?
NIS - Na+ Iodide symporter
How are thyorid hormones formed
Using E.R and Golgi .. who secrete Thyroglobullin - which will combine the iodines from diet to tyrosine.. 1 thyroglobullin has like 70 tyrosine molecules
What is organofication
Oxidizing iodine in tyorsine using Peroxidases
How are T.H activated?
Through nuclear trnascription, forming a RXR
Higher affinity for T3, so T4 are - 1 iodided to T3
Non Genomic T.H
- Regulation of ion channels
and
-Oxid phosphorylation
High and Low level of thyroid hormone on [ ] of fat
High level = dec [ ] cholest / phospholipid / TAG
but Inc F. FA