23.9

Question 1

Risk factors for Alzheimer’s disease?

Answer 1

Familial/genetic - chr 21 (APP mutations), chr 19 (ApoE), chr 14 (PS1), chr 1 (PS2)
Trisomy 21 i.e. Down’s syndrome
Gene dosage - Abeta/APP gene
Age! But age is not a risk factor unless there is an underlying predisposition

Question 2

What are the 4 types of AD?

Answer 2

Amnestic (temporal) - hippocampus!
Visuospatial (right hem. affected more than left)
Aphasic (left hem. affected more than right)
Frontal

Question 3

Many neurodegenerative diseases are associated with abnormal ___ conformations - toxic ___ of function.

Answer 3

Protein

Toxic gain of functions

Question 4

Amyloid plaques are formed by ___ and fibrillation of ___.

Answer 4

Polymerisation

Abeta

Question 5

Neurofibrillary tangles in the neuronal synapses are aggregates of ___ protein.

Answer 5

Tau

Question 6

Abeta monomers disperse onto membrane surface of the neuron at ___- and ___synaptic sites.

Answer 6

Extra- and intra-

Question 7

MPAC stands for ___-___ ___ ___ and inhibits oligomerisation of Abeta ___

Answer 7

Metal-protein attenuating compound

Monomers

Question 8

Solanezumab is a ___ ___ to Abeta.

Answer 8

Monoclonal antibody

Question 9

CJD is due to ___ infection of the brain.

Answer 9

Prion