23.3

Question 1

HM had a bilateral resection of the ___ ___ lobe (includes the hippocampus!) to treat severe epilepsy.

Answer 1

Medial temporal

Question 2

After surgery, HM had severe ___ amnesia but no other itellectual deficits.

Answer 2

Anterograde

Question 3

Declarative memory is ___ and conscious.

Answer 3

Explicit

Question 4

Non-declarative memory is ___ and unconscious.

Answer 4

Implicit

Question 5

Storage of memory depends on a glutamate receptor - ___. Mutant mice with abnormal ___ receptors had poor memory/recall.

Answer 5

NMDA

NMDA

Question 6

Long term changes/potentiation is important in storage of ___.

Answer 6

Memories

Question 7

Memories are stored in the ___ ___ ___ in the ___.

Answer 7

Medial temporal lobe in the hippocampus.

Question 8

In the short term, storage of memory depends on ___ receptors and insertion of ___ receptors (ionotropics, activated by glutamate), phosphorylation, and enhanced pre-synaptic release via retrograde signalling.

Answer 8

NMDA

AMPA

Question 9

In the long term, storage of memory depends on ___ synthesis and __ changes for long-term memory.

Answer 9

Protein synthesis and structural changes