2.3 lecture

Question 1

Homotropic effect

Answer 1

ligand that binds both sites is the same
-Ex: GrOES and GrOEL

Question 2

Heterotropic effect

Answer 2

ligand that binds sites are different
-Ex: Trp repressor

Question 3

allosteric effect

Answer 3

a ligand binding on a protein affects the binding properties of another part of the ligand

Question 4

Hill coefficient n = 1

Answer 4

binding is NOT cooperative

Question 5

Hill coefficient n > 1

Answer 5

positive cooperativity

Question 6

Hill coefficient n < 1

Answer 6

negative cooperativity

Question 7

Theta represents?

Answer 7

fractions of binding sites occupied

Question 8

What causes sickle cell anemia

Answer 8

Mutation of Glu6 to Valine