1.6 Flashcards
Which of the 3 immunorecognition complexes recognizes foreign molecules to initiate the innate immune response
Toll-like receptors
Which toll like receptors bind to triacyl lipopeptides?
TLR1/TLR2
Which toll like receptor requires a helper beta barrel protein to be activated?
TLR4
How many peptide chains are IgG antibody structures composed of?
4
How many constant domain barrels are there in an IgG light chain?
1
What is the function of the variable domain loops in an IgG molecule?
They contain the CDRs
How many possible unique antibodies may be generated through recombination of the IgG gene pool and alternative splicing of IgG encoding mRNA transcripts?
270,000,000
Toll like receptors
Recognize attacking pathogens and initiate immune response
Major Histocompatibility Complex (MHC) proteins
Activate T-helper cells to intimate the adaptive immune response, present antigen to antibody making cells to stimulate production of effective antibodies
Immunoglobulins/Antibodies
Bind and target antigen carrying attackers for killing/phagocytosis
TLR1/2 heterodimer with a triacyl lipopeptide structure
Ligand is sandwiched in an interior hydrophobic pocket
TLR3 dimer with dsRNA
Ligand is sandwiched across the exterior of both horseshoes
TLR4 dimer with lipopolysaccharide
2 ligand molecules inside carrier proteins separately bind the concave faces of the horseshoe structure
Triacyl-lipopeptides
TLR1 and TLR2 bind together to form triacyl-lipopeptides
MHC I presented ligands from the
Proteasome
