22/12/18 Flashcards

Microvascular complications

1
Q

What is pre-proliferative diabetic retinopathy represent?

A

retinal ischaemia

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2
Q

What is the treatment for pre-, proliferative and maculopathy?

A

Pan retinal photocoagulation

Grid photocoagulation

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3
Q

What value of HbA1C suggests Diabetes?

A

HbA1C>6.5

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4
Q

What is the mononeuritis complex?

A

Random combination of peripheral nerve lesions

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5
Q

What is mononeuritis complex?

A

Random combination of peripheral nerve lesions

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6
Q

What is ridiculopathy?

A

Pain over spinal nerves, usually affecting dermatome on the abdomen or chest wall

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7
Q

How do you treat Cushing’s syndrome?

A

Steroid synthesis inhibitors

Ketoconazole, metyrapone

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8
Q

Taking too much of what can cause cushing’s?

A

Taking too many steroids - glucocorticoids

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9
Q

What is used to treat primary hyperaldosteronism?

A

Spironolactone –> converted to canrenone

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10
Q

What is the difference between spironolactone and eplerone

A

Basically the same as spirnolactone but it is better tolerated - binds to preogertone and androgen receptors less.

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11
Q

How do you diagnose conn’s syndrome?

A

THINK - Hypertension suppresses the RAS = low renin. Also the low blood K+ Conn’s syndrome

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12
Q

What does high adrenaline cause?

A

Ventricular fibrillation –> death

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13
Q

What are the unwanted side effects of ketoconazole?

A

Nausea, vomiting, abdominal pain
Alopecia
Gynaecomastia, oligospermia, impotence, decreased libido. This is due to reduction of sex steroid production
Ventricular tachycardias
Liver Damage: Could be fatal. Patients are monitored with regular liver function tests

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