19/12/12

Question 1

How long can stores of thyroxine last?

Answer 1

1 month

Question 2

Aside from reducing levels of prolactin what else do D2 receptor agonist do?

Answer 2

Reduce the tumour size

Question 3

What are the side effects of somatostatin analogues?

Answer 3

Gi effects - Nausea, Diarrhoea and gallstones

Question 4

What class of compounds are IGF-1 and IGF-2?

Answer 4

Somatomedians

Question 5

What stimulates testosterone production and where?

Answer 5

LH in the leydig cells

Question 6

What does FSH stimulate in males?

Answer 6

Sertoli cells in the seminiferous tubules - sperm and inhibin A. Inhibin also has a negative feedback

Question 7

What are the three phases in the menstrual cycle?

Answer 7

Follicular phase
Ovulation
Luteal phase

28 days

Question 8

Define infertility?

Answer 8

Inability to conceive after 1 year of regular unprotected sex

Question 9

Define Azoospermia

Answer 9

Absence of sperm in ejaculate

Question 10

Define Oligospermia

Answer 10

Reduced number of sperm in ejaculate

Question 11

What converts testosterone to dihydrotestosterone?

Answer 11

5a-reductase

Question 12

What converts testosterone to 17b-oestradiol?

Answer 12

aromatase

Question 13

Clinical uses of testosterone

Answer 13

Increases:
Lean body mass
Muscle size and strength
Bone formation and bone mass
Libido and potency

Doesn’t restore fertility

Question 14

What are the causes of ovarian failure?

Answer 14

1) Premature ovarian failure
2) Ovariectomy
3) Ovarian dysgenesis

Question 15

How do you treat amenorrhoea?

Answer 15

Treat the cause (low weight)
Primary ovarian failure - infertile, HRT
Hypothalamic/pituitary disease - HRT for oestrogen replacement, Gonadotrophins