20/12/18 Flashcards

Endocrinology of pregnancy

1
Q

What enzymes are released in the acrosome reaction?

A

Hyalauronidase and Proteolytic enzymes

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2
Q

What is layer of cells on the outside of a blastocyte?

A

Trophoblast cells - forms chorion (placenta)

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3
Q

What causes epididymal secretions?

A

Androgens

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4
Q

What factor promotes angiogenesis during decidualisation?

A

TGF-b

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5
Q

What is inactive and acitive forms of vitamin D called?

A

Calciferol –> Calcitriol

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6
Q

What does calcium bind to on PT, causing what to occur?

A

It binds to calcium sensing receptors - which inhibits PTH secretion

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7
Q

Normal serum range of Ca2+

A

2.2-2.6 mmol/L

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8
Q

Apart from affecting calcium what else does vitamin D?

A

Increases phosphate reabsorption in the gut

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9
Q

What are the causes for low PTH?

A

Autoimmune

Magnesium deficiency - required for PTH to work

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10
Q

What are the diagnostic features of high Ca2+ but low PTH characteristic of?

A

hypercalcaemia of malignancy

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11
Q

What is used to treat vitamin D deficient patients with renal failure?

A

Alfacalcidol - 1a hydroxycholecalciferol

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