21- Schizophrenia Flashcards

1
Q

What is schizophrenia?

A
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2
Q

What are the three classes in to which schizophrenia symptoms can be grouped?

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3
Q

What schizophrenia symptoms are classed as positive?

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4
Q

What schizophrenia symptoms are classed as negative?

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5
Q

What schizophrenia symptoms are classed as cognitive?

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6
Q

How is schizophrenia diagnosed?

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7
Q

Describe in detail the symptoms of schizophrenia

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8
Q

How many phases are there in schizophrenia? What are they?

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9
Q

What is the prodrome?

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10
Q

What is the active/acute phase?

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11
Q

What is remission?

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12
Q

What is schizophreniform?

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13
Q

What is the aetiology of schizophrenia?

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14
Q

What do twin studies tell us about schizophrenia?

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15
Q

What are candidate genes?

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16
Q

What is the role of genetics in the aetiology of schizophrenia?

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17
Q

What kind of stresses can contribute to schizophrenia?

18
Q

Describe the role of environmental factors in the aetiology of schizophrenia

19
Q

What are the pathophysiology’s of schizophrenia?

20
Q

What dopamine pathways is schizophrenia associated with?

21
Q

What is the dopamine hypothesis of schizophrenia?

22
Q

What is the evidence against and for the dopamine hypothesis for schizophrenia?

23
Q

Describe the brain abnormalities in the brain structures of schizophrenics

24
Q

What is hypo frontality?

25
Q

How is NMDA receptor hypoactivity related to schizophrenia?

26
Q

What is the role of 5HT and what is its role in schizophrenics?

27
Q

What are the main current theories underlying the pathophysiology’s of schizophrenia?

28
Q

What are the treatment options available for schizophrenia?

29
Q

What are the main dopamine pathways?

30
Q

What are the two classes of antipsychotics?

31
Q

Compare typical and atypical antipsychotics

32
Q

What is the effect of D2 receptor blockade in the mesolimbic system?

33
Q

What is the effect of D2 receptor blockade in the nigro-striatal?

34
Q

What is the effect of D2 receptor blockade in the pituitary gland?

35
Q

What is the effect of D2 receptor blockade in the nucleus accumbens?

36
Q

What other receptors can antipsychotics block and what is the effect of this?

37
Q

How do antipsychotics cause sedation?

38
Q

What are the effects of an increase in prolactin?

39
Q

What is the effect of alpha-1 adrenoreceptor antagonism of antipsychotics?

40
Q

What are the anticholinergic effects of antipsychotics?