19- Depression Flashcards

1
Q

What is an affective disorder?

A
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2
Q

What are the characteristics of affective disorders?

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3
Q

What are the two types of depression?

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4
Q

What is unipolar depression?

A
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5
Q

What is bipolar depression?

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6
Q

How can bipolar depression be classified?

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7
Q

How is depression diagnosed?

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8
Q

How can the symptoms of depression be divided?

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9
Q

What are the emotional symptoms of depression?

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10
Q

What are the biological symptoms of depression?

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11
Q

What conditions can depression be co-morbid with?

A
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12
Q

What are the existing theories that describe the biological basis of depression?

A
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13
Q

Describe and explain the monoamine theory for depression

A
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14
Q

How do antidepressants increase the levels of monoamines to treat depression?

A
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15
Q

What is Reserpine?

A
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16
Q

What is the evidence against the monoamine theory?

A
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17
Q

What is the neuroendocrine theory?

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18
Q

What happens due to an increase in cortisol?

A
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19
Q

What is the HPA axis controlled by?

A

Amygdala
Hippocampus

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20
Q

Outline the negative feedback mechanisms of the HPA axis

A
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21
Q

How does activation of the hippocampus affect the HPA axis?

A
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22
Q

What does activation of the amygdala induce?

A
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23
Q

What are the causes for HPA axis dysfunction?

A

Hyperactivity of the amygdala
Hypoactivity of the hippocampus
- less suppression of the HPA axis
- rise in cortisol levels

24
Q

How can child neglect affect gene expression and cause depression?

25
What does tactile stimulation just after birth lead to?
26
How does SSRIs increase glucocorticoid receptors in the hippocampus?
27
What is the neuroplasticity and neurogenesis theory of depression?
28
How does an increase in glutamate levels lead to depression?
29
Describe the pathophysiology of depression
30
What are the treatments available for therapy?
31
What psychological treatments are available for the treatments of depression?
32
What pharmacological treatments are available for the treatments of depression?
33
What class of drugs are used as the first line of treatment for depression and why are they recommended?
34
What is the long term neurochemical effects of anti depressant usage?
35
What are MOAIs?
36
How do MAOIs work?
37
What is the effect of MAOIs?
38
How is MAOIs associated with food drug interactions?
39
What are the effects of NA accumulation?
40
How does reversible MAOI block the affect of an accumulation of NA due to food and drug interactions?
41
What are the therapeutic effects of tricyclic antidepressants?
42
What does the chronic treatment of tricyclic antidepressants lead to?
43
Can TCAs cause the cheese reaction and if not why?
44
What are SSRIs?
44
What are the main therapeutic effects of SSRIs?
45
What does an increase use of SSRIs lead to?
46
Why are SSRIs safer and better tolerated?
47
What side effects can SSRIs induce and how?
48
What is serotonin syndrome. how is it caused and what does it lead to?
49
Why does SSRIs take up to 2-3 weeks to impose their anti depressant affects?
50
What are some future developments of anti depresent drugs?
51
What are some problems that arise from anti depressants?
52
What disorder is lithium used to treat?
53
What is lithium's mode of cation in treating bipolar disorders?
54
What side effects can lithium cause?
55
What other treatments can be used to treat bipolar disorders?