2018/2019- Essay 2

Question 1

Title

Describe and compare the spontaneous and variant forms of CreutzfeldJakob desease (CDJ)

Answer 1

A Comparative Analysis of Spontaneous and Variant Forms of Creutzfeldt-Jakob Disease (CJD)

Question 2

Introduction- Paragraph 1

Describe and compare the spontaneous and variant forms of CreutzfeldJakob desease (CDJ)

Answer 2

CDJ
- Rara and fatal neurodegenerative disorder
- affects brain and NS (human and animals)
- 2 main forms: spontaneous form and variant form
- caused by abnorml prion proteins- accumulate in the brain
- neurological damage
- differ in symptoms, epidemiology and pathogenesis

Question 3

Spontaneous Form

Paragraph 2

Describe and compare the spontaneous and variant forms of CreutzfeldJakob desease (CDJ)

Answer 3

Spontaneous form of CDJ
- AKA sporadic CDJ
- Most common form
- due to misfolding of normal prion proteins->abnormal disease causing form
- >resulting from a chain reaction
- 85% of cases
- affects age grp:60-70s
- symptoms: memory loss,confusion, personality and behaviour changes

Disease progression
- muscle stiffness
- jerky movements
- difficulty; coordination and balance

Final Stage
-unreponsive patients
- vegetative state
- Causes unknown- spontaneous, normal prion proteins->abnormal dsease causing form
- >formation of amyloid plaques and spongiform changed in brain
- >results in neurodegenerative characteritic seen CJD

Question 4

Variant Form

Paragraph 3

Describe and compare the spontaneous and variant forms of CreutzfeldJakob desease (CDJ)

Answer 4

Variant form of CDJ
- aka mad cow disease /vCDJ
- Causes: eating contaminated meat from infected cattle
- >with bovine spongifor encephalopthy (BSE) - RELEASED PRION DISEASE
- Affects younger ages grps - onset of 28yrs
- psychiatric symptoms: depression/ anxiety
- neurological symptoms

Progression
- more rapid
- deat within a year of onset

Causes: abnormal prion proteins(found infected cattle when consumed)

Question 5

Conclusion- Paragraph 4

Describe and compare the spontaneous and variant forms of CreutzfeldJakob desease (CDJ)

Answer 5

-Causes: accumulation of abnormal prion proteins - brain and NS
Diifer: symptoms, epidemiology, pathogenesis
Sporadc CJD more common than vCJD

Important
prevention and treatment