20: Immune System Small Groups

Question 1

What factor is responsible for an increase in neutrophils?

Answer 1

G-CSF

Question 2

AID Hyper-IgM Syndrome

Answer 2

Without AID, pt cannot class switch to IgG or other Ab types

Question 3

X-linked CD40L Deficiency Hyper IgM

Answer 3

Defect in CD40L -> defects in both cellular and humoral immunities

Question 4

Major characteristic difference between AID Hyper IgM and CD40L Hyper IgM

Answer 4

CD40L Hyper IgM typically suffer from opportunitist infections

Question 5

LN difference between AID and CD40L HIGM

Answer 5

AID: enlarged LNs
CD40L: no GCs -> not enlarged LNs

Question 6

Opportunistic infection examples

Answer 6

Candida, CDiff, Pneumocystis jiroveci (carinii), cryptosporidium, toxoplasma gondii, cytomegalovirus