14: Metabolism Integration Flashcards
1
Q
Three systems of ATP generation from fastest to slowest and timelines involved
A
- ATP/Phosphagen system: 1-2 seconds of energy
- Anaerobic glycolysis: next 30 seconds of activity
- Aerobic respiration: long term energy
2
Q
How does the ATP/Phosphagen system work?
A
Regeneration of ATP by phosphocreatine
3
Q
Enzyme involved in ATP/Phosphagen system
A
Phosphocreatine kinase
4
Q
Where is phosphocreatine stored?
A
Muscles
5
Q
Fate of lactate from anaerobic glycolysis
A
Cori cycle: regeneration of glucose from lactate in the liver
6
Q
Leptin resistance
A
Similar to insulin resistance in that it is complex with many unknown factors, but it contributes to obesity
7
Q
SOCS
A
Suppressors of cytokine signaling: inhibit leptin and insulin receptors
8
Q
Three ways SOCS work
A
- Bind receptor
- Bind other signaling components
- Enhance proteolytic degradation of receptors
9
Q
SOCS knockout mice
A
Enhanced sensitivity to leptin -> resistant to weight gain even on high fat diet
