20- Hormones Flashcards
the endocrine system is made up of :
1-…..: located throughout the body
2-……: made by the glands and released into the bloodstream
3-……: recognize and respond to the hormones
1- glands
2-hormones
3- receptors
hormone must be present in adequate amount for the full action of another hormone
Permissiveness
- either nuclear or cytoplasmic
- these receptors are for steroid hormones
Internal receptors
- embedded in the lipid layer of the cell membrane
- these receptors are for the protein hormones
External receptors
- this mechanism of action hormone is seen in peptide hormones (adrenaline, insulin, TSH,)
- in order to pass the lipid layer, peptides have to bind to extracellular receptors present on the membrane.
Fixed receptor mechanism
external receptors
- seen in steroid hormones (hydrophobic)
- can cross the lipid layer
- the receptors are intracellular
Mobile receptor mechanism
secondary messenger of the mechanism of hormone action
cAMP
-located at the base of the brain
-secretes hormones that control the secretion of other endocrine glands. (except parathyroid gland)
-consists of 3 lobes :
1-anterior, largest, essential to life
2-intermediate, smallest lobe
3-posterior
Pituitary gland
hormones that control the production of other hormones are called
trophic hormones
rate of secretion is ………. proportional to the concentration in the blood
inversly
pituitary gland (anterior lobe) hormones:
1-….. : stimulates tissue, muscle, bone growth
2-…. : stimulates the thyroid gland to secrete hormones
3-…. : stimulates milk production
4-….. : stimulate secretion of glucocorticoids (cortisol) by the adrenal cortex (stress response)
1-Human-growth hormone (GH)
2-Thyroid stimulating hormone (TSH)
3-Prolactin (PRL)
4-Adrenocorticotropic hormone (ACTH)
a region of the brain immediately proximal to the pituitary gland
- links the nervous and endocrine systems
- secretes releasing and inhibiting hormones
- ADH (antidiuretic hormone): smooth muscle contraction during childbirth, milk ejection/secrete in response to uterine distention, stimulation of nipples
- oxytocin (OXT): decrease urine volume to save water/secrete in response to dehydration
Hypothalamus
- largest endocrine gland in the body
- uses iodine to make hormones(T3 and T4)
- control metabolism
Thyroid gland
when T3 and T4 levels are low in the blood, the pituitary gland releases more ………..
(TSH) thyroid-stimulating hormone
-glandular organ in the upper abdomen
1-exocrine function: trypsin and chymotrypsin to digest proteins/amylase(carbs/lipase(fats)
2-endocrine function: peptide hormones (insulin and glucagon)
the pancrease