2: TAG Synthesis And Degradation Flashcards
1
Q
TAG energy vs glycogen
A
TAG has about 6.75x more energy than glycogen by weight
2
Q
Three places where TAG synthesis takes place
A
Intestines, liver, adipocytes
3
Q
Four steps in intestinal synthesis of TAGs
A
- Dietary TAG broken into -> monoacyl glycerol + FFA by pancreatic lipase
- Intestinal cell resynthesized TAG using MAG + 2 FFAs
- TAG + apolipoproteins -> chylomicron
- Chylomicron released into lymph system
4
Q
What promotes TAG synthesis in hepatocytes and adipocytes
A
Excess carbs
5
Q
Four major lipases that work in TAG degradation
A
- ATGL-adipose triglyceride lipase
- Hormone-sensitive lipase
- Lipoprotein lipase
- MAG lipase
6
Q
Biggest factors that mobilize FAs from adipocytes
A
Hunger and exercise (glucagon and epi)
7
Q
Hormone sensitive lipase (HSL): is it active or inactive when phosphorylated?
A
Phosphorylated = active
8
Q
What do glucagon, epi, and insulin do to HSL
A
Glucagon/epi: phosphorylate HSL
Insulin: dephosphorylates HSL
9
Q
Perilipin function
A
Regulate lipolysis by controlling physical access of HSL to lipids
