1: Glycogen Metabolism Regulation Flashcards
When are glycogen synthase and glycogen phosphorylase active/inactive?
GS: active dephospho
GP: active phospho
When are glycogenesis and glycogenolysis favored?
Glycogenesis: fed state
Glycogenolysis: fasting state and during exercise
Three things that trigger glycogenesis
Blood glucose, insulin, ATP
Four things that trigger glycogenolysis
Glucagon, Ca in exercising muscles, AMP, low blood glucose
G6P effect on GS and GP
Stimulates GS, inhibits GP
Free glucose effect on GP
Inhibits GP in liver but not in muscle
Major effects of glycogen storage disorders that affect breakdown vs synthesis
Affect breakdown -> hepatomegaly, hypoglycemia
Affect synthesis -> dependent on glucose rather than glycogen
GSD 0 deficiency
GS (glycogen synthase)
GSD1a other name
Von Gierke Disease
GSD2 other name
Pompe disease
GSD3 other name
Cori disease
GSD4 other name
Andersen disease
GSD5 other name
McArdle disease
GSD6 other name
Hers Disease
GSD7 other name
Tarui disease
