2- pharmacology arthtitis Flashcards

1
Q

what are the basic pharmacology steps for pain treatment?

A
  1. step 1 = non opioid like paracetamol or NSAID
  2. step 2= weak opioid like codeine
  3. step 3 = strong opioid like morphine

→aim is to get manageable/controlled pain (not zero pain)

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2
Q

what are NSAIDs that can be used if GI symptoms?

A

COX 2 inhibitors like celecoxib or etoricoxib

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3
Q

what are some opiates analgesics?

A

= codeine or tramadol

co codamol has mix of 2 analgesics

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4
Q

why do we try limit opiate use?

A

drowsy, nauseous, fatigue, limit due to opiate dependent (limit for short period)

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5
Q

what are the commonly used DMARDs?

A

methotrexate, sulphasalazine, leflunomide, hydroxychloroquine

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6
Q

what medication do you give to people with RA before DMARDs start to work?

A

steroids like prednisolone

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7
Q

what conditions are DMARDs used to treat?

A

rheumatoid arthritis, psoriatic arthritis, connective tissue disease, vasculitis

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8
Q

when would you move onto using biologics after DMARDs?

A

after failure of 2 DMARDs (one of which is methotrexate)

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9
Q

what biologic is 1st line (what does it target)?

A

anti-TNf

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10
Q

what are some examples of anti-TNF drugs?

A

etanercept, adalimumab, certolizumab, infliximab, golimumab

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11
Q

what medication groups are used in gout acute flare?

A
  • colchicine
  • NSAIDs
  • steroids
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12
Q

what are medications that could be used in gout prophylaxis?

A

allopurinol is 1st line then febuxostat 2nd line (both xanthine oxidase inhibitors so stops uric acid production)

also uricosurics e.g. probenecid, sulphinpyrazone, benzbromarone →make pee out

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