2. How we breathe Flashcards
2 zones of lung
1) Conducting zone
2) Respiratory zone (blood-gas interface)
Conducting zone
no gas exchange
trachea to terminal bronchioles
generations 0-16
BULK FLOW
Respiratory zone
Volume 2.5-3 L
respiratory bronchioles, alveolar ducts and alveolar air sacs
generations 17-23
DIFFUSION
Boyle’s Law
P1V1 = P2V2
Intrapleural pressure
between pleural membranes
Intrapulmonary pressure
in the alveoli
Transpulmonary pressure
Intrapulmonary minus Intrapleural
Flow
Pressure x resistance
Asthma
Reduced airway radius
Increased resistance
Intermittent smooth muscle contraction
Vital capacity (VC)
Maximum volume breathed out SLOWLY after maximum inspiration
Forced vital capacity (FVC)
Maximum volume breathed out as QUICKLY as possible after maximum inspiration
Forced expiratory volume in 1 second (FEV1)
Volume expired in 1s during FVC
Values for Normal/Obstructive/Restrictive FEV1/FVC
Main site of airway resistance
Intermediate bronchi
How are CRV, TLC, FRC measured?
Plethysmography
sealed chamber