2: Hemodynamics Flashcards
Edema vs effusion
Edema: abnl fluid in interstitial space
Effusion: abnl fluid in potential spaces / body cavities (pleural space, peritoneal space, pericardial space, joint space)
Most important colloidal protein in oncotic pressure
Albumin
Kwashiorkor and how it causes edema
Protein deficiency -> insufficient albumin -> reduced plasma oncotic pressure
Three main mechanisms that lead to decreased protein -> decreased plasma oncotic pressure
- Not enough ingested
- Not enough produced by liver
- Too much lost via kidney disease
Possible differentials for lymphedema
Infection, inflammation, trauma, tumors, surgery, malformation, helminth infection by Filariasis
Lymphedema in pt s/p breast cancer surgery and axillary dissection
Removing draining LNs from the breast can cause lymphedema -> edema in upper extremity on that side
Chronic congestion and hemosiderosis
Chronic congestion can allow RBCs to escape vessels -> hemosiderin escapes and causes tissue damage
Normal hepatic blood flow in the liver
From portal tract -> towards central vein
Endothelial organelles that create vWF
Weibel Palade bodies
Syndromes caused by lack of vWF vs lack of GpIb receptor
Lack of vWF: bon Willebrand disease
Lack of GpIb: Bernard Soulier syndrome
What do ADP and thromboxane A2 do in primary hemostasis
ADP: increase platelet activation
Thromboxane A2: increase platelet aggregation
What does Aspirin block?
Thromboxane A2
Disorder caused by deficiency in GpIIb-IIIa
Glanzmann thrombasthenia
S/S that point to possible primary hemostasis
Muco cutaneous bleeding (nose bleeds, gums bleeding), easy bruising, metromenorrhagia
Lab testing to see if there is something wrong with primary hemostasis
- CBC for platelet quantity
- Platelet function studies
- Flow cytometry
- PFA-100: tests adhesion and aggregation
Other name for factor I and II
I: fibrinogen
II: prothrombin