2. Functional Neuroanatomy & Neurophysiology Flashcards
The brain is suspended in what?
Cerebrospinal fluid (CSF)
The brain is the centre of…
Cognition, emotion, behaviour and consciousness
Santiago Ramon y Cajal was a Spanish anatomist who studied what?
The structure of the nervous system by going through slices of the brain tissues to create a picture of neurons and what they look like
Outline the neurone ‘doctrine’
Neurons…
- Are the basic unit of the NS
- Are distinct and separate from each other (they are not interconnected)
- Have cells bodies, axons and dendrites
- Transmit information (in one direction only)
What are the 4 ways in which the neuron receives and processes signals?
- Collects information
- Integrates information
- Conducts information
- Outputs information
What are the 3 ways in which we know that neurons connect to other neurons?
- Can stimulate other neurons
- Can inhibit other neurons
- Can send output to many neurons
What do dendrites do & what zone are they referred to?
They seek information from other neurons and are considered the input zone
Cell body acts as which zone?
The integration zone
Information travels down the axon to the axon terminals where….
A synapse will connect the axon terminals to another neuron
What are the 2 main cells in the NS?
Neurons and Glia
Describe features of Neurons and Glia
The ‘building blocks’ of the nervous system
Small
Low contrast under a microscope
Which cell is the main cell of the NS and which has a more supportive role?
Neurons = main Glia = supportive
Neurons can connect to make __, __, or __
Circuits, chains or networks
Give an example of a circuit, chain and network
Circuit - simple reface arc
Chains - retina
Networks - convergence and divergence
Where are networks present?
In the cortex
The function of a neural circuit depends on…
- How the neurons are connected
- How strong the connections are
- Whether the synapses are excitatory (EPSP) or inhibitory (IPSP)
What is critical between excitatory and inhibitory synapses?
Balance
What do Glia cells not take part in?
The signalling or processing
What is the main function of glia cells?
To sustain the neurons by ensuring that nutrients are supplied to the neurons
What are the 2 functions that glia cells are through to have?
Protective function and metabolic function
What are the 4 types of glia?
Astrocytes
Oligodendrocytes
Schwann cells
Microglia
Astrocytes attach to blood vessels and neurons to provide…
Physical support as well as blood and oxygen
How do astrocytes ensure that each neuron gets enough oxygen?
By detecting how active neurons are and providing the sufficient nutrients required
What is the function of astrocytes in terms of synapses?
They keep them separate and clean up any debris
What is the main function of oligodendrocytes?
To support and insulate axons which speeds up neurotransmission (the myelin sheath)
Oligodendrocytes latch around the axon and excels their membrane around it multiple times to serve as…
An electrical insulation - myelination
Oligodendrocytes are only found where?
The CNS
What is multiple sclerosis?
A demyelinating disease which causes issues with motor and cognitive functions
Describe the 3 main functions of microglia and which disease they may be responsible for
- Precursors of blood cells
- Part of the brain’s immune system
- Related to macrophages (eats up debris_
May be responsible for Alzheimers
The CNS is made up of what?
The brain and spinal cord
The PNS (Peripheral nervous system) is made up of what?
All nerves and neurons that reside outside, or extend beyond the CNS
What is a nerve?
An enclosed bundle of axons
Why is there great interest in medicine in the PNS?
Because lots of diseases can cause issues in the PNS
What are the structural subdivisions in the PNS?
Cranial nerves
Spinal nerves
How many pairs of cranial nerves are there?
12
How many pairs of spinal nerves are there?
31
What are the functional subdivisions of the PNS?
Somatic nervous system and the automatic nervous system
What is the somatic nervous system?
The part of the NS that regulates emotion and conscious sensations
What is the autonomic nervous system?
The unconscious part which keeps your body working
What are the two aspects of the ANS?
Sympathetic NS
Parasympathetic NS
What are cranial nerves really important for?
Our perceptions
All our main senses are connected via them
Spinal nerves connect through…
‘Branches’ which are known as roots
Outline the different pairs of spinal nerves
8 cervical nerve pairs, 12 thoracic nerve pairs, 5 lumbar nerve pairs, 5 sacral nerve pairs, 1 coccygeal nerve pair
Each nerve has a ___ root (2 different types)
Ventral root and Dorsal root
What does the ventral root contain?
Efferent fibres (projecting away from the CNS - come from the brain back to the spinal cord)
What does the dorsal root contain?
Afferent fibres (projecting towards the CNS - come from the spinal cord to the brain)
What does the sympathetic nervous system do?
Prepares the body for action - fight/flight response
What does the parasympathetic nervous system do?
Generally helps the body to relax, recuperate and prepare for future action
The CNS is the ___ part of the nervous system
Largest
What is the CNS cushioned by and protected by?
Cushioned by fluid and protected by bone
What are the membranes that cover the CNS called?
Meninges