2. Feline Retroviral Diseases Flashcards
What are the two major feline retroviruses?
FeLV and FIV
What is the pathogenesis of Felv?
Bite wounds
Secretions: Saliva, blood, urine
viral replicaiton in local lymphoid tissue of oropharynx
Monocyte and lymphocyte
Replication in bone marrow
What are the 3 possible types of FeLV infecitons?
Progressive - viremic, ill, signs
Regressive - transient viremia
Abortive - none
Describe test results for each of the following:
Progressive
Regressive
Abortive
Progressive: Elisa +, IFA +
Regressive: Elisa +, IFA -
Abortive: Elisa -, IFA -
What is the prognosis for Felv?
80% die in 3 years
Poor, only live 3 years
-Immune suppression
-Infections
-Hematologic disorders
-Neoplasia
What is the pathogenesis of FIV?
Infection local lymphatic tissue
Fever, lymphadenopathy, lymphopenia, Viremia dissemination, deplete CD4, decreased lymphocyte, asymptomatic years, progressive immunosuppression
What is the clinical manifestation of FelV?
Immune mediated disease, enteritis, hepatopathy, infertility, fading kitten syndrom, osteochondromatosis
What are the laboratory findings on FIV cats?
Will be positive if vaccinated or disease
How long does it take an FeLV test to be positive after infection?
30 days
How long does it take an FIV test to be positive after infection?
60 days
What diagnostic tests are used for FIV?
FIV antibodies (Elisa or western bot)
+ = infected, vaccine, false + or maternal antibodies
- = not infected, not seroconverted
PCR - falst +/-
What is the prognosis for FIV?
Good no change in lifespan
What protein does the FeLV test look for?
P 27
What are risk factors for FeLV?
Young kitten
Outdoors
High density
Bite, saliva, nasal secretion, milk, urine, feces
Inteuro, nursing
In FeLV when lymphoma and leukemia are common, viremia is dependent on tumor location. Where is it worst?
Mediastinal
Who should you test for FeLV?
Kittens, outdoor animals, sick cats, unknown exposure, blood donor
How do you treat FeLV?
Treat the associated diseases
Does the FeLV vaccine make a cat positive for it?
NO
(FIV does though)
What is a possible side effect of the FelV vaccine?
Sarcoma
What are clinical findings in FIV?
Mild or inapparent
Chronic immune suppresion
Neoplasia
How do you treat FIV?
Azidothymidine
